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肝癌是中国高发恶性肿瘤。由于其广泛的肿瘤异质性，最新的靶向联合免疫治疗的方案仅对20~30%的患者有效，并且缺乏指导精准用药的药敏分子分型。因此亟需研究可以指导肝癌精准用药的分子分型和揭示新的耐药靶点。
近日，中南大学基础医学院肿瘤研究所研究员陶永光团队与湘雅医院刘双研究员和肖德胜团队在国际肿瘤学期刊Molecular Cancer（IF=41.444）发表了题为“The chromatin‑associated RNAs in gene regulation and cancer（在基因表达和癌症中的染色质相关RNA）”的综述。肖德胜教授、刘双研究员和陶永光研究员为本论文的共同通讯作...
Journal for ImmunoTherapy of Cancer丨罗敏/卢智刚团队报道瘤内注射激活STING的纳米疫苗提高抗肿瘤免疫效果（图）
卢智刚团队 肿瘤免疫 生物医学研究院
2023/4/14
整合含有天然免疫刺激分子的纳米制剂、以及个性化新抗原筛选技术，使肿瘤疫苗在临床测试展现了令人瞩目的有效性。新一代的肿瘤疫苗与CAR技术﹑免疫检查点干预成为免疫治疗中重要的三大板块。然而，在很多病人中，T细胞无法通过肿瘤屏障进入瘤内，导致对多种免疫治疗的不敏感；因此促进T细胞进入肿瘤，逆转肿瘤微环境成为提高免疫治疗效果的重要步。
越来越多的研究表明，在多种肿瘤组织内存在一小部分致瘤能力特别强、分化程度极低并具有干细胞的自我更新及多向分化特性的细胞，称为“肿瘤干细胞（Cancer Stem Cells, CSCs）”。醛脱氢酶1A1（Aldehyde dehydrogenas 1A1，ALDH1A1）是乳腺肿瘤干细胞（Breast Cancer Stem Cells，BCSCs）的重要生物标志物之一。研究发现，ALDH1A...
近日，深圳大学医学部金哲教授团队在《Molecular Cancer》(IF:27.4)发表了题为“A novel protein AXIN1-295aa encoded by circAXIN1 activates the Wnt/β-catenin signaling pathway to promote gastric cancer progression”的原创研究成果。该研究发现Circ...
徐建青、张晓燕教授团队《Journal for ImmunoTherapy of Cancer》报道一种全新的、肿瘤微环境激活杀伤的CAR-T，有潜力成为不同实体瘤有效治疗手段（图）
张晓燕教授 生物医学研究院 实体瘤 CAR-T疗法
2023/4/14
近年来，CAR-T疗法治疗血液源性肿瘤效果显著，然而在针对实体瘤的临床研究中却遭遇重大挑战。目前CAR-T均为靶点激活杀伤，而肿瘤靶点通常也在正常组织低表达，进而产生“on-target, off-tumor”现象、诱生炎症因子风暴、中枢神经毒性等，给CAR-T治疗带来严重的安全隐患。肿瘤细胞的异质性进一步导致靶点激活杀伤有效性受到挑战。即目前的靶点激活杀伤的CAR-T技术在在治疗实体瘤中，安全性...
许杰课题组《Journal for Immunotherapy of Cancer》揭示THADA在驱动PD-L1高尔基体驻留中的作用以及肿瘤免疫靶标价值（图）
许杰课题组 癌细胞 免疫检查点
2023/4/17
癌细胞中程序性死亡配体1（PD-L1）的异常上调抑制T细胞介导的细胞毒性，但驱动和维持PD-L1表达的分子机制仍不完全清楚。PD-L1在肿瘤细胞内高尔基体等细胞器的驻留可能是影响抗体药物疗效的因素之一，但既往对其理解并不充分，使免疫检查点阻断疗法面临挑战。
When to choose radiotherapy for prostate cancer, and what technique?
prostate cancer radiotherapy
2017/4/10
This review describes the present curative role of radiotherapy in men with localised prostate cancer, and the many technical innovations that have occurred over the last 20 years that have improved i...
What consent model is ethically justifiable in cancer population research?
Harm epidemiological studies the data connection
2017/2/22
The important role that explicit informed consent plays in the conduct of research cannot be denied. Inhumane medical research has prompted over many decades the articulation of guidelines, legislatio...
Current ethical issues in advanced cancer care
Continuous treatment cancer symptom management cancer treatment clinical doctors
2017/2/22
Despite continuing advances in treatment, cancer continues to be a major cause of suffering and death, and so symptom management and end of life care will continue to be an important aspect of cancer ...
Ethical issues around phase I and phase III clinical trials in cancer
Cancer clinical trials clinical practice drug toxicity
2017/2/22
The results of phase III (randomised) cancer clinical trials underpin evidence-based clinical practice. A standard comparator (control arm) is crucial so that the real value of an intervention can be ...
Negotiating limits to the funding of high cost cancer medicines
Drugs health budgets cancer drugs cancer clinical
2017/2/22
The cost of pharmaceuticals is overwhelming health budgets around the world. A growing proportion of this burden stems from the ever-increasing demand for subsidisation of cancer medicines. Those maki...
Ethical issues arising in the use of genomics in cancer
ethical issues genomics cancer genomics cancer modern genomics clinical practice
2017/2/22
This paper examines ethical issues in relation to genomics that arise in connection with their use in cancer, focusing primarily on the clinical context. The role of genomics in cancer is investigated...
Ethical aspects of cancer screening
Screening for cancer cancer clinical public health clinical ethics
2017/2/22
Screening for cancer or cancer risk is well-established in high-income countries. This article considers ethical aspects of cancer screening. Ethical evaluation of screening depends on a contested evi...