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对广东省清远市电子垃圾拆解区的蔬菜、大米、鸡蛋和饮用水样品中镍进行测定，评估其非致癌健康风险，计算各样品的每日摄入量（DI）及危险系数（HQ）。该电子垃圾拆解区，大米和鸡蛋镍的含量分别为（0.46±0.24）、（0.16±0.13）μg/g，均高于对照区[大米和鸡蛋镍的含量分别为（0.17±0.03）、（0.02±0.02）μg/g]（P值均<0.05）。大米、蔬菜、鸡蛋和饮用水的DI值分别为（3...
烟酸受体GPR109A介导的烟酸作用机制研究进展
动脉粥样硬化 烟酸受体 潮红 G蛋白偶联受体
2012/4/19
烟酸作为调脂药物应用于临床已经50多年,相对高剂量的烟酸具有广泛的调脂作用。越来越多的证据表明，烟酸单用或联合降低低密度脂蛋白胆固醇（LDL-C）药物使用能够延缓动脉粥样硬化（AS）的进程和降低发生心血管事件的风险；但它的作用机制一直不是很明确。2003年, 三个研究小组同时发现了烟酸受体,使人们对烟酸的作用机制有了进一步认识。烟酸受体GPR109A是一种Gi蛋白偶联受体，主要表达于白色、棕色脂肪...
Influence of titanium dioxide nanoparticles on speciation and bioavailability of arsenite
Arsenic TiO 2 Nanoparticles Bioaccumulation Carp Facilitated transport
2013/12/12
In this study, the influence of the co-existence of TiO2nanoparticles on the speciation of arsenite [As(III)]was studied by observing its adsorption and valence changing. Moreover, the influence of Ti...
The status of malaria before and after distribution of ITNs from 1999 to 2006 in two districts of Khammouanne Province, Lao P.D.R
malaria Khammouanne Province Lao P.D.R
2010/12/10
In 1999, an insecticide-treated net (ITN) distribution project was started in several malaria-endemic villages in Lao P.D.R., namely Vientiane, Bolikhamxay and Khammouanne Provinces. After the complet...
Air Pollution Induced Asthma and Alterations in Cytokine Patterns
Air Pollution Asthma Cytokines
2010/2/4
In recent decades, clinicians and scientists have witnessed a significant increase in the prevalence of allergic rhinitis and asthma. The factors underlying this phenomenon are clearly complex; howeve...
铂类络合物引起的DNA O6-AGT的耗竭及染色体损伤
宁辛铂 Mer细胞
2010/3/3
本文测定了KB,CHL,HL-60和L1210细胞DNA鸟嘌呤O6-烷基转移酶(O6-AGT)活性。结果表明,KB细咆有较高的O6-AGT活性,系Mer+细胞。而CHL,HL-60和L1210细胞的O6-AGT活性低,属于Mer-细胞。在此基础上我们观察了顺铂(DDP)、宁辛铂(樟脑胺氯乙酸铂,CCP)和碳铂(JM-8)对KB(Mer+)细胞O6-AGT的影响及Mer+和Mer-细胞的杀伤及微核的...