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北京基因组所（国家生物信息中心）马利娜副研究员等应邀在国际权威综述期刊Nature Reviews Molecular Cell Biology发表长非编码RNA数据库评述文章
马利娜 非编码RNA数据 蛋白编码
2023/7/6
202年5月23日，中国科学院北京基因组研究所(国家生物信息中心)马利娜副研究员应Nature Reviews Molecular Cell Biology 邀请，联合章张研究员，发表题为“The contribution of databases towards understanding the universe of long non-coding RNAs”的评述，系统总结了长非编码RNA...
随着单细胞技术的迅速发展和应用，越来越多的细胞类型和细胞多态性被发现。准确的细胞分类对于描绘细胞类型多样性、追踪细胞谱系、表征肿瘤微环境以及阐明发育和疾病复杂机制至关重要。
基因转录是中心法则的关键环节，以DNA为模板产生RNA用于蛋白质合成。从简单多细胞生物到人，转录水平的调控是基因差异性表达的关键，决定了个体的生长、发育和衰老等几乎所有生命活动。发生在基因启动子区的转录起始过程是基因表达调控的核心，受到来自染色质结构、染色质重塑、组蛋白和DNA的表观遗传修饰以及增强子区转录因子和转录共激活因子（如Mediator）的招募等多重因素的调控，细胞在这些复杂且精密的调控...
多次跨膜蛋白入核需要经过膜表面蛋白提取、从膜上脱落与跨膜运输多阶段步骤，在此过程中必须保护多个疏水跨膜结构域免受胞质亲水环境影响并保持蛋白空间构象。因此，传统观点认为跨膜蛋白以膜性结构局限定位在细胞膜/内膜中发挥生物学功能。2021年6月7日、2022年2月23日Cell Research连续2篇文章发表了上海交通大学医学院附属第一人民医院王红霞团队关于四次跨膜蛋白入核信号调控的研究成果。
浙江大学生命科学研究院2021年8月17日宋海卫和黄俊课题组在Cell Discovery上合作发表论文解析了INTS3/INTS6蛋白质复合物参与DNA损伤修复的分子与结构基础（图）
宋海卫 黄俊 蛋白质复合物 基因
2022/10/25
2021年8月17日，浙江大学生命科学研究院宋海卫课题组和黄俊课题组合作在Cell Discovery上发表了题为“Crystal structure of the INTS3/INTS6 complex reveals the functional importance of INTS3 dimerization in DSB repair”的研究论文。该论文在分子水平上揭示了INTS3的二聚化...
L-selectin gene polymorphism and its association with clinical mastitis, somatic cell score, and milk production in Polish Holstein-Friesian cattle
SELL udder inflammation milk production traits cows
2018/11/23
Bovine mastitis is a widespread disease of the mammary gland, highly contributing to the increase in veterinary costs in dairy industry. In the present study, the genetic polymorphism within bovine L-...
Identification of a Minimal Cis-element and Cognate Trans-factors Required for the Regulation of Rac2 Gene Expression during K562 Cell Differentiation
Rac2 Gene Expression
2015/5/25
This dissertation examines the molecular mechanisms regulating Rac2 gene expression during cell differentiation and identification of a minimal cis-element required for the induction of Rac2 gene expr...
REGULATION OF CHOP TRANSLATION IN RESPONSE TO eIF2 PHOSPHORYLATION AND ITS ROLE IN CELL FATE
Stress (Physiology) Messenger RNA Apoptosis
2015/5/25
In response to different environmental stresses, phosphorylation of eukaryotic initiation factor-2 (eIF2) rapidly reduces protein synthesis, which lowers energy expenditure and facilitates reprogrammi...
Patients with the genetic disorder tuberous sclerosis complex (TSC) suffer from neoplastic growths in multiple organ systems. These growths are the result of inactivating mutations in either the TSC1 ...
The integrated stress response directs cell fate decisions in response to perturbations in protein homeostasis
diabetes cancer
2015/5/25
Disruptions of the endoplasmic reticulum (ER) cause perturbations in protein folding and result in a cellular condition known as ER stress. ER stress and the accumulation of unfolded protein activate ...
Novel Systems for the Functional Characterization of Genes Related to Paclitaxel Metabolism in Taxus Cell Cultures
agrobacterium cell culture paclitaxel
2015/1/5
Human society has benefited greatly from plant secondary metabolites, often utilizing a variety of compounds as dyes, food additives, and drugs. In particular, pharmaceutical development has benefited...
Notch 1 Mediated Inhibition of Nur77-induced apoptosis: Implications for T-cell Leukemia
Apoptosis Calcium IP3R Leukemia Notch1 Nur77
2014/12/10
It is widely accepted that activating mutations of genes encoding the Notch family of transmembrane receptors, specifically Notch1, are associated with oncogenic transformation. Previous data from our...
Characterization Of The Zebrafish Umleitung (uml) Mutant: Essential Roles For The Transmembrane Protein Brother Of Cdo (Boc) In Regulating Hedgehog (Hh) Mediated Cell Differentiation And Neural Patterning
Biological sciences Axon guidance Hedgehog signaling Morphogen gradients Neural patterning Pituitary
2014/12/10
The secreted Hedgehog (Hh) molecule acts as a morphogen, mitogen, and cell survival factor during embryogenesis and during later growth and tissue homeostasis periods in vertebrates. Hh plays these di...
A Novel Approach For Stable, Cell-Type Restricted Knockdown of Gene Expression in C.ELEGANS
Biological sciences Cell-type restricted knockdown Gene expression C. elegans
2014/12/10
Removal of protein activity by genetic mutation or pharmacological inhibition has been used extensively to understand the normal function of a protein. However, null mutations eliminate gene function ...
Stochastic modeling of gene activation and application to cell regulation
Stochastic modeling gene activation application regulation
2010/11/15
Transcription factors (TFs) are key regulators of gene expression. Based on the classical scenario in which the TF search process switches between one-dimensional motion along the DNA molecule and fre...