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Immunoglobulin gene diversification and B-cell ontogeny in cattle
Health and environmental sciences Immunoglobulin Gene diversification Cattle B cells
2015/1/28
The anatomical compartment within which the B-cell develops is different in different animals. This study attempts to trace B-cell ontogeny in cattle by investigating the expression profile of B-cell ...
Chlamydia-host cell interactions: Studies of lipid rafts, caveolin proteins, the glycolipid exoantigen (GLXA) and intermediate filament proteins
Chlamydia infections infectious bacterial disease infection vaccine protein
2015/1/28
Chlamydial infections are the most commonly reported infectious bacterial diseases. However, very little is known about the complex host-parasite interactions that allow this pathogen to evade host de...
The SOS response in Escherichia coli: Single cell analysis using fluorescence microscopy
Biological sciences DNA repair RecA SOS response
2015/1/28
During the course of DNA replication, replication forks often stall or collapse as they proceed from oriC to the terminus due to housekeeping types of DNA damage or proteins bound to DNA. If the DNA i...
鉴定痢疾杆菌毒力基因的SW480细胞模型构建Construction of SW480 Cell Model Identifying Shigella Virulent Genes
SW480 细胞模型 痢疾杆菌 信号标签诱变技术 构建
2008/1/8
摘要
信号标签诱变技术（STM）是一种在体内高通量筛选病原体毒力基因的新方法，在应用时的一个先决条件是要建立合适的体内筛选系统。为将该技术应用于福氏痢疾杆菌，我们使用三个福氏痢疾杆菌菌株进行了预试验：通过同源重组构建而成的带有氯霉素抗性且aroA和virG基因失活的突变株RC426；因在侵袭质粒上自发缺失3个基因座(ipaBCDA, invA 和 virG)的另一减毒突变株T32，其曾被用作福氏...
缘悭一面廿五年――纪念我所在Cell杂志发表论文25周年
神经细胞 蛋白质 微生物
2007/12/29
2005年1月14日出版的美国生命科学权威杂志《细胞》发表了中国科学家（蒋辉、郭纬、梁新华和饶毅）关于发现对确定神经细胞极性起关键作用的蛋白质的研究论文。国内多家媒体报道，这是近25年来中国内地学者第一次在《细胞》杂志上发表论文。