搜索结果: 1-4 共查到“知识库 遗传学 Cell”相关记录4条 . 查询时间(0.163 秒)
PTEN是一个关键的抑癌基因，其蛋白在肿瘤中经常发生缺失。PTEN蛋白的缺失可由遗传学和表观遗传学因素导致，但在肿瘤中PTEN蛋白的缺失比例常常比其基因突变、缺失比例要高很多，因此PTEN蛋白的降解成为肿瘤中研究的一个热点问题。以往研究发现，PTEN蛋白可受到多种翻译后修饰并转移到蛋白酶体进行降解，也有少量研究发现PTEN可经由溶酶体途径降解，但PTEN溶酶体降解的具体分子机制尚不清楚。
线粒体是细胞内一类非常重要的细胞器，具有独立于细胞核的遗传物质（mtDNA）及相应的基因转录和蛋白翻译系统。与此同时，线粒体也是细胞代谢的重要区室，因其在能量代谢中的重要作用被称为“细胞的能量工厂”。线粒体代谢和生物合成异常在肿瘤、心血管疾病、神经退行性疾病、衰老等疾病的进程中具有关键的调控作用。线粒体量在细胞内被动态调节，并与细胞的代谢状态密切相关。目前对细胞如何感知营养状态调控核编码线粒体基因...
Complex Systems Analysis of Arrested Neural Cell Differentiation during Development and Analogous Cell Cycling Models in Carcinogenesis
Cell cycling control of cell division and the neoplastic transformation in carcinogenesis essential roles of high c-Myc p27 Inhibition p53 inactivation and hTERT activation of Telomerase biosynthesis in Malignant Cell Transformation Rational Clinical trials Individualized Medicine and potential for optimized Radio-Chemo- Gene- and Immuno- therapies of Cancers Ł ukasiewicz models of Genetic Networks Genome and cell interactomics models in terms of categories of Ł ukasiewicz logic Algebras and Lukasiewicz Topos Ł ukasiewicz Topos with an n-valued Ł ukasiewicz Algebraic Logic subobject classifier genetic network transformations in Carcinogenesis developmental processes and Evolution/ Evolutionary Biology Relational Biology of Archea yeast and higher eukaryotic organisms nonlinear dynamics in non-random hierarchic genetic networks proteomics coupled genomes via signaling pathways mechanisms of neoplastic transformations of cells and topological grupoid models of genetic networks in cancer cells natural transformations of organismic structures in Molecular Biology
2015/7/30
A new approach to the modular, complex systems analysis of nonlinear dynamics of arrested neural cell Differentiation--induced cell proliferation during organismic development and the analogous cell c...
XPC DNA REPAIR PROTEIN REGULATION IN THE CONTEXT OF THE G1/S CELL CYCLE CHECKPOINT
XPC DNA repair retinoblastoma protein cell cycle
2015/5/21
DNA is subject to various types of damage that can impair cellular function or cause cell death. DNA damage blocks normal cellular processes such as replication and transcription and can have catastro...