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2013年,美国国立卫生研究院启动“使用先进革新型神经技术的脑研究计划”(Advancing Innovative Neurotechnologies (BRAIN) Initiative),简称脑计划,致力于发展新型研究手段,力求对人脑获得深入且革新性认识。来自全球多个国家和地区的多家组织和科研机构参与这一计划,其研究领域涵盖了生物学,物理学,工程学乃至临床医学(https://brainini...
Dislocation-mediated growth of bacterial cell walls
Cell wall growth Biophysics Defects Biological Physics
2012/5/29
Recent experiments have illuminated a remarkable growth mechanism of rod-shaped bacteria: proteins associated with cell wall extension move at constant velocity in circles oriented approximately along...
Hypoxic Cell Waves around Necrotic Cores in Glioblastoma: A Biomathematical Model and its Therapeutic Implications
Glioblastoma multiforme tumor hypoxia pseudopalisades invasion mathematical model
2012/5/2
Glioblastoma is a rapidly evolving high-grade astrocytoma that is distinguished pathologically from lower grade gliomas by the presence of necrosis and microvascular hiperplasia. Necrotic areas are ty...
Pattern formation in a cell based auxin transport model with numerical bifurcation analysis
Pattern formation cell auxin transport model numerical bifurcation analysis
2012/2/28
Transport models of growth hormones can be used to reproduce the hormone accumulations that occur in plant organs. Mostly, these accumulation patterns are calculated using time step methods, even thou...
Formation of BCR Oligomers Provides a Mechanism for B cell Affinity Discrimination
Formation BCR Oligomers Provides Mechanism B cell Affinity Discrimination
2012/2/28
B cells encounter antigen over a wide affinity range. The strength of B cell signaling in response to antigen increases with affinity, a process known as "affinity discrimination". In this work, we us...
An acoustically-driven biochip - Impact of flow on the cell-association of targeted drug carriers
acoustically-driven biochip - Impact flow cell-association targeted drug carriers
2011/8/11
Abstract: The interaction of targeted drug carriers with epithelial and endothelial barriers in vivo is largely determined by the dynamics of the body fluids. To simulate these conditions in binding a...
Computing fluxes and chemical potential distributions in biochemical networks: energy balance analysis of the human red blood cell
Metabolioc networks energy balance analysis thermodynamic efficiency
2011/8/16
Abstract: The analysis of non-equilibrium steady states of biochemical reaction networks relies on finding the configurations of fluxes and chemical potentials satisfying stoichiometric (mass balance)...