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EXPLORING SIMILARITIES AND VARIATIONS OF HUMAN MOBILITY PATTERNS IN THE CITY OF LONDON
time-series cluster analysis smart card data human mobility spatiotemporal patterns
2018/11/9
The availability of new spatial data represents an unprecedented opportunity to better understand and plan cities. In particular, extensive data sets of human mobility data supply new information that...
Time of day and eating behaviors are associated with the composition and function of the human gastrointestinal microbiota
circadian rhythms microbiome eating patterns eating frequency early energy consumption overnight-fast duration timing of eating humans adults
2018/11/20
Background: Preclinical research has shown that the gastrointestinal microbiota exhibits circadian rhythms and that the timing of food consumption can affect the composition and function of gut microb...
Michael John Rennie, MSc, PhD, FRSE, FHEA, 1946–2017: an appreciation of his work on protein metabolism in human muscle
Michael John Rennie protein metabolism muscle
2018/11/14
Michael Rennie died suddenly in his sleep on 9 January 2017, although he had not been well for some time. He was 70 y old. Mike is best known for his work on skeletal muscle: the regulation of its mas...
Impact of polyunsaturated and saturated fat overfeeding on the DNA-methylation pattern in human adipose tissue: a randomized controlled trial
DNA methylation epigenetics EWAS Illumina 450k methylation array LIPOGAIN cohort obesity overfeeding polyunsaturated fat prediction saturated fat
2018/11/13
Background: Dietary fat composition can affect ectopic lipid accumulation and, thereby, insulin resistance. Diets that are high in saturated fatty acids (SFAs) or polyunsaturated fatty acids (PUFAs) h...
Impact of human milk pasteurization on gastric digestion in preterm infants: a randomized controlled trial
digestion Holder pasteurization human milk infant nutrition preterm infant
2018/11/12
Background: Holder pasteurization has been reported to modify human milk composition and structure by inactivating bile salt–stimulated lipase (BSSL) and partially denaturing some of its proteins, pot...
Alterations in human milk leptin and insulin are associated with early changes in the infant intestinal microbiome
milk leptin insulin the infant intestinal microbiome
2018/11/12
We read with great interest the study by Lemas et al. (1) that reported early changes in the gut microbiota composition and functions of exclusively breastfed infants born from obese mothers compared ...
Is human white adipose tissue bright during exercise?
human white adipose tissue bright exercise
2018/12/13
Adipose tissue has traditionally been divided into 2 distinct types: white adipose tissue and brown adipose tissue. White adipose tissue is traditionally regarded as an energy store, in which chemical...
Targeted delivery of short-chain fatty acids to the human large bowel
Targeted delivery short-chain fatty large bowel
2018/11/30
The cecum and colon are an integral, but somewhat neglected, part of the human digestive system. This digestion is affected not by human enzymes but by the microbiota that degrade undigested dietary c...
Ultra-long–term human salt balance studies reveal interrelations between sodium, potassium, and chloride intake and excretion
sodium salt chloride potassium aldosterone urine diet electrolyte intake
2018/11/30
Background: The intake of sodium, chloride, and potassium is considered important to healthy nutrition and cardiovascular disease risk. Estimating the intake of these electrolytes is difficult and usu...
Electrostatic Fields Near the Active Site of Human Aldose Reductase:2.New Inhibitors and Complications Caused by Hydrogen Bonds
Humans Nitriles Aldehyde Reductase Spectrophotometry, Infrared Spectroscopy, Fourier Transform Infrared Binding Sites Catalytic Domain Protein Binding Kinetics Hydrogen Bonding
2016/5/25
Vibrational Stark effect spectroscopy was used to measure electrostatic fields in the hydrophobic region of the active site of human aldose reductase (hALR2). A new nitrile-containing inhibitor was de...
Electrostatic Fields Near the Active Site of Human Aldose Reductase:1.New Inhibitors and Vibrational Stark Effect Measurements
apoptosis ATM cisplatin IKK p73 ubiquitination
2016/5/25
Vibrational Stark effect spectroscopy was used to measure electrostatic fields in the hydrophobic region of the active site of human aldose reductase (hALR2). A new hALR2 inhibitor was designed and sy...
Spectroscopic Study of Ser92 Mutants of Human Myoglobin:Hydrogen Bonding Effect of Ser92 to Proximal His93 on Structure and Property of Myoglobin
Carbon Monoxide Cyanides Escherichia coli Ferric Compounds Ferrous Compounds Histidine Humans Hydrogen Bonding Magnetic Resonance Spectroscopy Mutagenesis Myoglobin Myoglobin Oxygen Polymerase Chain Reaction Recombinant Fusion Proteins Serine Serine Spectrophotometr Spectrum Analysis, Raman Structure-Activity Relationship
2016/5/23
Neutron diffraction studies have demonstrated that the hydroxyl group oxygen of Ser92(F7) is hydrogen bonded to the proximal His93(48) N epsilon H proton in myoglobin (Mb) [Cheng, X., & Shoenborn, B. ...
Ultrafast Measurements of Geminate Recombination of NO with Site-specific Mutants of Human Myoglobin
human myoglobin mutagenesis kinetics structure-function relationships picosecond timescale
2016/5/23
Flash photolysis studies of NO recombination to heme proteins offer a direct probe of protein structural changes on the tens of picoseconds timescale where they can be compared with molecular dynamics...
Dynamics of Protein Relaxation in Site-Specific Mutants of Human Myoglobin
Humans Cysteine Heme Alanine Myoglobin Recombinant Proteins Spectrophotometry Mutagenesis,Site-Directed Amino Acid Sequence Protein Conformation
2016/5/23
We have recently reported spectroscopic evidence for structural relaxation of myoglobin (Mb) following photodissociation of MbCO [Lambright, D. G., Balasubramanian, S., & Boxer, S. G. (1991) Chem. Phy...
Perturbations of the Distal Heme Pocket in Human Myoglobin Mutants Probed by Infrared Spectroscopy of Bound CO:Correlation with Ligand Binding Kinetics
Distal Heme Pocket Human Myoglobin Mutants Probed Infrared Spectroscopy Bound CO:Correlation Ligand Binding Kinetics
2016/5/23
The infrared spectra of CO bound to human myoglobin and myoglobin mutants at positions His-64, Val-68, Asp-60, and Lys-45 on the distal side have been measured between 100 and 300 K. Large differences...