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朱卫国教授团队在《Nature Structural & Molecular Biology》发文揭示DNA损伤修复起始阶段染色质乙酰化的调控新机制（图）
DNA 朱卫国教授 生物学 赖氨酸
2023/10/23
DNA损伤应答与修复经历“进入-修复-恢复” (Access-Repair-Restore，ARR）三个生物学过程。核小体稳态对于DNA损伤应答及信号解除、基因转录瞬时激活与抑制至关重要。单就组蛋白赖氨酸乙酰化来说，乙酰化介导染色质松弛以便DNA修复推进或促进基因转录；去乙酰化则造成致密染色质结构以保护遗传物质不受损失或抑制基因转录，因此染色质松散被认为是DNA双链断裂修复（DSBs）的先决条件。...
植物分子生物学，研究植物基因及基因组表达调控的分子机理, 开展农林业物种（如毛竹、杉树、水稻, 茶叶等）的基础分子生物学研究。深入进行模式植物的分子生物学研究, 以求揭示植物基因转录过程的分子机理, 基因表达调控在植物生长发育,光感应,与逆境感应信号传递过程中的作用, 以及其在农林业物种产量与品质控制过程中的作用。
An Application for Downloading and Integrating Molecular Biology Data
downloading molecular biology data integrating data
2015/5/26
Integrating large volumes of data from diverse sources is a formidable challenge for many investigators in the field of molecular biology. Developing efficient methods for accessing and integrating th...
An Application of a Variable Window Discrete Scan Statistic in Molecular Biology
Amino acids Moving sums Product-type approximation Scan statistic
2015/3/18
In this article a variable window discrete scan statistic is introduced for a
conditional scan statistic. This statistic is used to test the null hypothesis that the
observations are randomly distri...
An Application for Downloading and Integrating Molecular Biology Data
downloading molecular biology data integrating data
2015/1/9
INTRODUCTION AND BACKGROUND Integrating large volumes of data from diverse sources is a formidable challenge for many investigators in the field of molecular biology. Developing efficient methods for ...
Molecular Biology of a Surface-Exposed Protein Family of Bartonella Bacilliformis
Bartonella Bacilliformi Surface-Exposed Protein
2015/1/7
Bartonella bacilliformis (Bb) is the bacterial agent of Carrión's disease and is presumed to be transmitted between humans by phlebotomine sand flies, most notably Lutzomyia verrucarum. Carrión's ...
Molecular Biology of Polyketide Biosynthesis
polyketides biosynthetic pathway engineering Streptomyces rimosus oxytetracycline
2009/3/20
Streptomyces species and related genera synthesize a large number of secondary metabolites, many of which are biologically active. Amongst them, polyketides is the largest class. Polyketides are a str...
Advances and Prospects in Molecular Biology of Tree
Advances Prospects Molecular Biology of Tree
2009/3/6
Advances and Prospects in Molecular Biology of Tree.
It is important, given the potential use of MIS as an anticancer agent against tumors of Mullerian duct origin, that the search continue to identify binding isoforms of the MIS type II receptor or...
Molecular Biology and Pharmacology of PDE-5—Inhibitor Therapy for Erectile Dysfunction
Molecular Biology Pharmacology PDE-5—Inhibitor Therapy Erectile Dysfunction
2008/12/19
In light of newly emerging selective phosphodiesterase type 5 (PDE-5) inhibitors, it is necessary to understand the basic biochemical and pharmacological principles of PDE-5 inhibitor action (Corbin a...
Fungal Inulinases: Enzymology, Molecular Biology and Biotechnology
ethanol fermentation filamentous fungi immobilized enzyme inulinase molecular evolution
2008/4/20
Inulin is a fructan in which linear chains of β-(2→1)-linked D-fructofuranose molecules are attached to sucrose at the reducing end. Inulinases have been encountered in higher plants and in microorgan...
视黄醇结合蛋白及其基因的分子生物学Molecular Biology of the Retinol-binding Proteins and Their Genes
视黄醇结合蛋白 视黄醇结合蛋白基因 繁殖性能
2008/1/10
摘要
视黄醇结合蛋白（RBP）是一类维生素A（VitA）的运载蛋白，参与血清和细胞内视黄醇/视黄酸的转运，是疏水小分子结合蛋白家族的成员。这类RBP主要在肝脏中合成并释放入血液进而进入各种组织。血清RBP通过与视黄醇、前白蛋白及细胞表面受体相互作用，在VitA 的储存、代谢、转运到周围靶器官中具有重要功能；细胞RBP则主要在细胞内发挥类似作用。本文介绍了视黄醇结合蛋白的作用机理、组织定位和发育性...
摘要
单细胞真核藻类—小球藻是一种重要的微藻资源。近年来，随着藻类生物技术的迅速发展，有大量关于小球藻的研究工作被报道。在分子生物学领域，研究则集中在小球藻的核基因组和叶绿体基因组、重要功能基因的克隆和分析以及以小球藻为载体的基因工程研究等方面，本文仅就此方面的进展作一综述。Abstract: Unicellular green alga Chlorella is a kind of impor...
New Approach to Teaching Basic Science Courses: Biochemistry and Molecular Biology in the Block System of Curricular Design
New Approach Teaching Basic Science Courses Biochemistry Molecular Biology Block System Curricular Design
2016/3/14
The overarching goal for curricular content in Biochemistry and Molecular Biology was to enable students apply basic science material to the clinical setting. The traditional curricular delivery syste...
A Biotechnology Course Emphasizing Molecular Biology and Practical Experience
Biotechnology Course Emphasizing Molecular Biology Practical Experience
2016/3/10
This article describes a new course offered to graduate and undergraduate students (in an all PharmD program) at Mercer University School of Pharmacy. The primary objective of this course is to prepar...