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LOSS OF SIMPL INCREASES TNFα SENSITIVITY DURING HEMATOPOIESIS
SIMPL colony assay hematopoietic stem cell
2015/5/26
The innate and adaptive immune responses are critical for host survival. The TNFα/NF-κB signaling pathway is a major regulator of the immune response. The TNFα/NF-κB signaling pathway has also been pr...
ERK1 AND ERK2 IN HEMATOPOIESIS, MAST CELL FUNCTION, AND THE MANAGEMENT OF NF1-ASSOCIATED LEUKEMIA AND TUMORS
hematopoiesis neurofibroma leukemia
2015/5/25
Neurofibromatosis type 1 is a genetic disease that results from either heritable or spontaneous autosomal dominant mutations in the NF1 gene, which encodes a protein serving, at least in part, to acce...
SIRT1 DEFICIENCY COMPROMISES MOUSE EMBRYONIC STEM CELL DIFFERENTIATION, AND EMBRYONIC AND ADULT HEMATOPOIESIS IN THE MOUSE
Mouse Embryonic Stem Cell Hematopoietic Cell Differentiation
2015/5/21
SIRT1 (Sirtuin 1) is a founding member of a family of seven proteins and histone deacetylases. It is involved in cellular resistance to stress, metabolism, differentiation, aging, and tumor suppressio...
Paraplegia Due to Extramedullary Hematopoiesis in the Thalassemia Intermedia
Extramedullary hematopoiesis paraplegia thalassemia
2009/6/24
Extramedullary hematopoiesis (EMH) is a rare condition encountered in chronic hemolytic disorders. In order to compensate for long-lasting anemia in thalassemia, intermedia extramedullary hematopoiesi...
Large Splenic Mass of Extramedullary Hematopoiesis
Computed Tomography splenic mass extramedullary hematopoiesis
2010/2/4
The imaging findings of focal splenic, presacral and paraosseous extramedullary hematopoiesis in a 35-year-old man with ß-thalassemia major are described with particular reference to ultrasonogr...