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Growing Prospects of Dynamic Covalent Chemistry in Delivery Applications
Dynamic Covalent Chemistry delivery Growing Prospects
2024/1/11
Delivery remains a major obstacle restricting the potential action of small molecular drugs as well as novel biologics which cannot readily enter cells without the help of a vector. A successful activ...
Trends in the Diels-Alder reaction in polymer chemistry
REVERSIBLE CLICK CHEMISTRY FREE-RADICAL POLYMERIZATION CROSS-LINKED POLYAMIDES HIGH-PERFORMANCE ACRYLIC-ACID ROOM-TEMPERATURE MALEIC-ANHYDRIDE LEVOPIMARIC ACID BUILDING-BLOCK MUCONIC ACID
2023/12/4
The Diels-Alder (DA) reaction is regarded as quite a useful strategy in organic and macromolecular syntheses. The reversibility of this reaction and the advent of self-repair technology, as well as ot...
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输卵管作为精卵结合的必经之路,其微环境对精子在输卵管中的定向运动及后期的成功受精极为关键。临床发现,并非精力充沛、运动速度快的精子能够在众多竞争中胜出,而是埋伏在输卵管壁面绒毛内的精子,等待合适的时机才能迁移到卵子附近完成受精。然而,对精子与输卵管上皮细胞表面的相互作用,以及从静态到苏醒并迁移的过程,现有的实验方法和理论研究仍颇受挑战。
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近日,深圳大学医学部生物医学工程学院林静特聘教授团队在国际顶级学术期刊《Angewandte Chemie International Edition》(影响因子15.336,中科院一区,TOP期刊)上发表了题为《A “Self-Checking” pH/Viscosity-Activatable NIR-II Molecule for Real-Time Evaluation of Photot...
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郭睿教授团队在《New Journal of Chemistry》和《Journal of Inorganic Biochemistry》发表研究成果:报道功能化的Fe3O4纳米颗粒和氧化石墨烯作为纳米药物载体靶向递送抗癌药物并有效杀死肝癌细胞(图)
恶性肿瘤 郭睿教授 肝癌 山西医科大学
2023/12/21
肝癌是世界范围内威胁人类健康的恶性肿瘤之一。临床上常见的治疗方式包括化疗与手术治疗等,然而化疗由于用药量大、药物靶向作用弱等缺点给患者带来了一系列严重副作用。因此,亟需设计并构筑一种具有良好的肝癌细胞靶向作用的多功能纳米药物载体,用于靶向递送抗癌药物并杀死肝癌细胞。
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常州大学石油化工学院银凤翔-陈标华课题组在ACS Sustainable Chemistry & Engineering上发表研究论文(图)
陈标华课题组 石油化工学院 锂 纯相金属 电催化
2023/2/16
纯相金属-有机骨架(MOFs)具有超高的比表面积和较高活性的金属中心,在锂-空气电池催化领域中有巨大的应用潜力。然而这类材料的微孔特性限制了锂-空气电池的充放电容量。为解决这一问题,银凤翔、陈标华课题组开发了一种部分移除配位官能团的方法,在Cu离子与均苯三甲酸配位过程中引入间苯二甲酸,从而在微孔Cu-MOF中构造了大量的介孔以及具有不饱和配位的Cu金属中心。
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李青山教授、班树荣教授团队在《The Journal of Organic Chemistry》发文:新颖的高度区域和立体选择性催化合成环戊烯类衍生物(图)
李青山教授 山西医科大学 药学院
2023/12/22
2019年11月,药学院李青山教授和班树荣教授团队在中科院top期刊《The Journal of Organic Chemistry》发表了题为“Diastereo- and Enantioselective Synthesis of Functionalized Cyclopentenes Containing a Quaternary Chiral Center via a Thiosqua...
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顾宏周课题组与合作者《Nature Chemistry》报道利用DNA纳米组装体按尺寸精确分选脂质体新策略用于曲率依赖的膜相关反应研究(图)
粒径 曲率 DNA 纳米 囊泡 物医学研究院
2023/4/17
在细胞中,无论是胞内囊泡与细胞器还是胞外的分泌囊泡,大量膜蛋白可以在具有极高曲率的弯曲膜上 (曲率半径<50 nm)分布并维持其结构域,为了理解这些膜蛋白与高曲率膜的依存关系及其功能行为,人们亟需一种模型体系进行膜结构的仿生研究,而粒径大小精确可控的脂质体可以提供这样的理想平台(粒径与曲率成反比)。在现有的脂质体制备策略中,粒径大小的调控依赖于制备条件、均一化的处理方式及纯化方式等,但得到的脂质体...
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阿尔兹海默症(Alzheimer disease,AD)是一种神经系统退行性疾病,以记忆障碍、失语、失用、失认、视空间技能损害等为主要症状。据世界卫生组织统计,截止2018年底,全球痴呆人数已经超过5000万人,其中AD患者约占70%,AD已成为影响全球的重大公共健康问题。
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氧气还原、氧气析出以及氢气析出等小分子电催化反应是锌空气电池、锂空气电池、燃料电池以及电化学分解水制氢等能量存储与转换技术的核心反应,然而它们均是动力学慢反应,都需要使用催化剂来加速它们的反应,从而提高存储和转换效率。在单一催化剂上实现多功能电催化一直是该领域研究的热点和重点,这对于降低上述能量存储与转换器件结构的复杂性、大幅度提高性能,促进它们的产业化都具有重要意义。
Antihyperlipidemic Statins: A Self-Contained, Clinically Relevant Medicinal Chemistry Lesson
medicinal chemistry dyslipidemia hyperlipidemia statins
2018/4/9
Medicinal chemistry instruction at Creighton University is designed to provide an in-depth, scientifically grounded and clinically relevant learning experience for pharmacy students. Each topic covere...
The Importance of Medicinal Chemistry Knowledge in the Clinical Pharmacist’s Education
Importance Medicinal Chemistry Knowledge Clinical Pharmacist’s Education
2018/11/21
Objective. To show why medicinal chemistry must be a key component of the education of pharmacy students, as well as in the pharmacist’s practice.
Findings. Five case reports were selected by their c...
Geology and Mineral Chemistry of Gold Mineralization in Mirge-Naqshineh Occurrence (Saqez, NW Iran): Implications for Transportation and Precipitation of Gold
gold quartz veins mineral chemistry EPMA Mirge-Naqshineh Iran
2018/4/10
The Mirge-Naqshineh gold district is situated at northwest of Iran with a NW-trending brittle-ductile shear zone. It is hosted by Precambrian meta-sedimentary and meta-volcanic units traversed by mine...
Preface: Evolution of the solar system: New advances in cosmochemistry and planetary chemistry
cosmochemistry planetary chemistry
2017/4/10
The understanding of evolution of solar system has been
recently entered a phase of major change with the results
of new astronomical observation, several primitive extraterrestrial
samples includi...
Stark Spectroscopy:Applications in Chemistry,Biology and Materials Science
electroabsorption electrochromism electro-optic absorption electric field charge transfer
2016/5/23
Stark spectroscopy has been applied to a wide range of molecular systems and materials. A generally useful method for obtaining electronic and vibrational Stark spectra that does not require sophistic...