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The influence of WC1 isoforms on gammadelta T cell function
Scavenger receptor WC1 molecules diversity rich cysteine membrane surface glycoprotein T cells
2014/12/11
WC1 molecules are an extensively diversified family of integral type 1 scavenger receptor cysteine rich (SRCR) membrane glycoproteins expressed on the surface of arteriodactyls such as sheep, cattle, ...
Investigations of glycoprotein co-translational maturation in the cell
New protein Protein Endoplasmic reticulum cavity Protein folding Coupling molecules Fold the sensor Membrane glycoprotein
2014/12/11
The earliest steps of nascent protein folding are critical to the overall folding efficiency. Folding events start as soon as the protein is translocated into the endoplasmic reticulum lumen, where th...
Notch functions from the cytoplasm to the nucleus during T cell activation
Cytokines T cells activate cells cell signal
2014/12/11
Notch1 specifically upregulates expression of the cytokine interferon-γ in peripheral T cells through activation of NF-κB. However, how Notch mediates NF-κB activation remains unclear. NF-κB activatio...
Regulation of Notch signaling by the E3 ubiquitin ligase Cbl-b and its role in CD4+ T cell anergy
Cell life cycle T cell signal T cell activation and E3 ubiquitin ligase
2014/12/11
Notch signaling is an evolutionarily conserved pathway that mediates a variety of cell fate decisions. In the immune system, the Notch pathway plays an important role throughout the life of T cells. C...
WC1 mediates T cell activation and is required for the response of bovine gammadelta T cells to Leptospira antigen
Biological sciences T cell activation Leptospira
2014/12/11
Workshop cluster 1 (WC1) molecules are exclusively expressed on the surface of γδ T cells. They belong to the scavenger receptor cysteine-rich (SRCR) superfamily and are encoded by a multiple-gene fam...
Notch 1 Mediated Inhibition of Nur77-induced apoptosis: Implications for T-cell Leukemia
Apoptosis Calcium IP3R Leukemia Notch1 Nur77
2014/12/10
It is widely accepted that activating mutations of genes encoding the Notch family of transmembrane receptors, specifically Notch1, are associated with oncogenic transformation. Previous data from our...
Beyond cell Adhesion: Exploring the Role of Cadherin-11 Extracellular Processing by ADAM Metalloproteases in Cranial Neural Crest Migration
ADAM Cadherin Cell migration Cell signaling Cranial neural crest Developmental biology/Embryology
2014/12/10
The migration of the cranial neural crest is an essential part of cranio-facial development in every vertebrate embryo. The cranial neural crest (CNC) is a transient population of cells that forms the...
Characterization Of The Zebrafish Umleitung (uml) Mutant: Essential Roles For The Transmembrane Protein Brother Of Cdo (Boc) In Regulating Hedgehog (Hh) Mediated Cell Differentiation And Neural Patterning
Biological sciences Axon guidance Hedgehog signaling Morphogen gradients Neural patterning Pituitary
2014/12/10
The secreted Hedgehog (Hh) molecule acts as a morphogen, mitogen, and cell survival factor during embryogenesis and during later growth and tissue homeostasis periods in vertebrates. Hh plays these di...
Effects of Phytochemicals from Rhodiola crenulata on Highly Invasive Breast Cancer Cell Lines and Embryonic Models of Migration
Cancer Mammary Metabolism Metastasis Natural Product Rhodiola crenulata
2014/12/10
The root of the Tibetan plant Rhodiola crenulata is part of eastern traditional medicine. Studies have suggested that members of the Rhodiola genus display anticancer properties. In this study we exam...
A Novel Approach For Stable, Cell-Type Restricted Knockdown of Gene Expression in C.ELEGANS
Biological sciences Cell-type restricted knockdown Gene expression C. elegans
2014/12/10
Removal of protein activity by genetic mutation or pharmacological inhibition has been used extensively to understand the normal function of a protein. However, null mutations eliminate gene function ...
Regulation and Action of Skp2 and Rhoa in Cell and Tumor Models: Investigation into the Molecular Mechanisms Responsible for the Aggressive Phenotype of Triplenegative Breast Cancer
Basal-Like Breast Cancer Cell Cycle p27 proliferation SKP2 Triple-Negative Breast Cancer
2014/12/10
Breast cancer tops the list of new cancer cases and is predicted to be the second leading cause of cancer deaths in women in 2012. The primary objective of the present study was to provide insights in...
Proteolytic Regulation of CtrA, the Master Regulator of Cell Cycle in Caulobacter crescentus
Caulobacter proteolysis CtrA SciP
2014/12/9
Cell cycle progression in Caulobacter crescentus depends on the master regulator, CtrA. During the transition from swarmer to stalk cell (G1 to S phase), CtrA is degraded by the AAA+ protease ClpXP an...
Control of inflammation, helper T cell responses and regulatory T cell function by Bcl6
cells microRNAs eosinophilic esophagitis asthma
2015/5/21
Regulatory T (Treg) cells represent an important layer of immune-regulation indispensible for curtailing exuberant inflammatory responses and maintaining self-tolerance. Treg cells have translational ...
Twist1 and Etv5 are part of a transcription factor network defining T helper cell identity
Twist1 Etv5
2015/5/21
CD4 T helper cells control immunity to pathogens and the development of inflammatory disease by acquiring the ability to secrete effector cytokines. Cytokine responsiveness is a critical component of ...
Defining the mechanism of prostaglandin E₂-enhanced hematopoietic stem and progenitor cell homing
Prostaglandin Homing HIF1-alpha
2015/5/21
Hematopoietic stem cell (HSC) transplantation is a lifesaving therapy for a number of hematological disorders. However, to be effective, transplanted HSCs must efficiently “home” to supportive niches ...