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Exome Sequencing in an Admixed Isolated Population Indicates NFXL1 Variants Confer a Risk for Specific Language Impairment
Exome Sequencing Admixed Isolated Population NFXL1 Variants Specific Language Impairment
2015/5/13
Children affected by Specific Language Impairment (SLI) fail to acquire age appropriate language skills despite adequate intelligence and opportunity. SLI is highly heritable, but the understanding of...
Genome-wide analysis identifies a role for common copy number variants in specific language impairment
Genome-wide analysis copy number variants specific language impairment
2015/5/13
An exploratory genome-wide copy number variant (CNV) study was performed in 127 independent cases with specific language impairment (SLI), their first-degree relatives (385 individuals) and 269 popula...
Defining the biological bases of individual differences in musicality
musicality individual differences genetics aptitude tests
2015/5/13
Advances in molecular technologies make it possible to pinpoint genomic factors associated with complex human traits. For cognition and behaviour, identification of underlying genes provides new entry...
Asymmetry within and around the human planum temporale is sexually dimorphic and influenced by genes involved in steroid hormone receptor activity
Planum temporale Asymmetry Genome-wide association scan Sexual dimorphism Steroid hormones
2015/5/13
The genetic determinants of cerebral asymmetries are unknown. Sex differences in asymmetry of the planum temporale (PT), that overlaps Wernicke's classical language area, have been inconsistently repo...
Brain dynamics in the comprehension of action-related language. A time-frequency analysis of mu rhythms
Mu rhythms Beta rhythms Embodied meaning Action language Perceptive language
2015/5/13
EEG mu rhythms (8–13 Hz) recorded at fronto-central electrodes are generally considered as markers of motor cortical activity in humans, because they are modulated when participants perform an action,...
A de novo FOXP1 variant in a patient with autism, intellectual disability and severe speech and language impairment
FOXP1 variant autism intellectual disability severe speech language impairment
2015/5/13
FOXP1 (forkhead box protein P1) is a transcription factor involved in the development of several tissues, including the brain. An emerging phenotype of patients with protein-disrupting FOXP1 variants ...
Genome wide identification of Fruitless targets suggests a role in upregulating genes important for neural circuit formation
Genome wide identification upregulating genes neural circuit
2015/5/6
The fruitless gene (fru) encodes a set of transcription factors (Fru) that display sexually dimorphic gene expression in the brain of the fruit-fly; Drosophila melanogaster. Behavioural studies have d...
Association study of fibroblast growth factor genes and brain volumes in schizophrenic patients and healthy controls
fibroblast growth brain volumes schizophrenic patients healthy controls
2015/5/6
Fibroblast growth factors (FGFs) play crucial roles in brain development and neuroprotection and have been implicated in the susceptibility to schizophrenia (Terwisscha van Scheltinga et al., 2010). F...
Understanding communicative actions: A repetitive TMS study
Experimental semiotics Posterior superior temporal sulcus MTt Transcranial magnetic stimulation Raven
2015/5/6
Despite the ambiguity inherent in human communication, people are remarkably efficient in establishing mutual understanding. Studying how people communicate in novel settings provides a window into th...
Increased Pain Intensity Is Associated with Greater Verbal Communication Difficulty and Increased Production of Speech and Co-Speech Gestures
Increased Pain Intensity Greater Verbal Communication Difficulty Speech Co-Speech Gestures
2015/5/6
Effective pain communication is essential if adequate treatment and support are to be provided. Pain communication is often multimodal, with sufferers utilising speech, nonverbal behaviours (such as f...
Shining a light on CNTNAP2: complex functions to complex disorders
CNTNAP2 neurogenetics language disorder
2015/5/6
The genetic basis of complex neurological disorders involving language are poorly understood, partly due to the multiple additive genetic risk factors that are thought to be responsible. Furthermore, ...
Hypnotizability and Catechol-O-Methyltransferase (COMT) polymorphysms in Italians
hypnotizability attention COMT absorption selective genotyping haplotype analysis
2015/5/6
Higher brain dopamine content depending on lower activity of Catechol-OMethyltransferase (COMT) in subjects with high hypnotizability scores (highs) has been considered responsible for their attention...
Genome-wide association analyses of child genotype effects and parent-of-origin effects in specific language impairment
ALSPAC GWAS imprinting neurodevelopmental disorder specific language impairment
2015/5/5
Specific language impairment (SLI) is a neurodevelopmental disorder that affects linguistic abilities when development is otherwise normal. We report the results of a genome-wide association study of ...
Associations of HLA alleles with specific language impairment
Specific language impairment (SLI) HLA Neurodevelopmental disorders Genetic association
2015/5/5
Human leukocyte antigen (HLA) loci have been implicated in several neurodevelopmental disorders in which language is affected. However, to date, no studies have investigated the possible involvement o...
H3M2:detection of runs of homozygosity from whole-exome sequencing data
H3M2 runs of homozygosity whole-exome sequencing data
2015/5/5
Motivation: Runs of homozygosity (ROH) are sizable chromosomal stretches of homozygous genotypes, ranging in length from tens of kilobases to megabases. ROHs can be relevant for population and medical...