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In the five years since the FDA’s initial approval of chimeric antigen receptor (CAR) T cell therapy, Penn Medicine has gleaned 20 additional approvals related to drugs and techniques to treat or dete...
Every three to five days, all of the cells lining the human intestine are replaced. That constant replenishment of cells helps the intestinal lining withstand the damage caused by food passing through...
中国科学院植物研究所牡丹种质创新与应用研发团队以3个牡丹品种‘姚黄’‘黑天鹅’‘百园红霞’,2个芍药品种‘黄金轮’和‘红色魅力’(‘Red Charm’),以及一个组间杂交品种‘芭茨拉’(‘Bartzella’)的初开全花为供试材料,利用3种不同提取液提取其中的活性成分,使用液质联用技术对提取物中类黄酮成分进行定性和定量分析。共鉴定出26种类黄酮化合物,且以60%乙醇作为溶剂提取类黄酮效率最高。之...
近日,发表在《Science Advances》上的一项最新研究中,来自费城儿童医院和普林斯顿大学的研究团队在21个独立家庭中发现了一种与神经发育异常相关的新型遗传疾病。
纤维肌痛(FM)是一种难以诊断和治疗的神秘慢性疼痛疾病,以全身反复出现的广泛性疼痛为特征,常伴有疲劳、睡眠障碍、晨僵以及抑郁、焦虑等问题,其病因仍然不为人知。近期,波鸿鲁尔大学与海德堡大学的研究人员发现,参与疼痛处理的某些大脑区域在FM患者中功能异常。研究成果发表在《NeuroImage: Clinical》期刊,标题为“Neural correlates of control over pain...
The Basser Center for BRCA at Penn Medicine is the first comprehensive center for the research, treatment, and prevention of BRCA-related cancers.
In what may turn out to be a long-missing piece in the puzzle of breast cancer, Harvard Medical School researchers have identified the molecular sparkplug that ignites cases of the disease currently u...
近日,发表在《Nature Communications》上的一项新研究中,来自新加坡国立癌症中心、杜克-新加坡国立大学医学院等多家学术机构的联合研究团队发现了癌症如何逃避免疫系统后在体内转移的机制,并探索了抑制这一危险机制的可能性。该研究对开发癌症治疗的新策略具有重要意义。
Antibodies that can disarm a virus, known as neutralizing antibodies, are key to the body’s ability to fight off infection. MIT chemists have come up with a new way to identify these neutralizing anti...
Researchers have identified blood biomarkers that could help pediatricians quickly diagnose in children severe cases of COVID-19 as well as multisystem inflammatory syndrome, also known as MIS-C, a po...
MIT engineers have designed a two-component system that can be injected into the body and help form blood clots at the sites of internal injury. These materials, which mimic the way that the body natu...
Cancer drugs that stimulate the body’s immune system to attack tumors are a promising way to treat many types of cancer. However, some of these drugs produce too much systemic inflammation when delive...
造血干细胞(HSCs)在人类整个生命周期中再生血细胞,为了维持其健康状态,HSCs特别依赖于蛋白质稳态。然而,HSCs如何清除错误折叠的蛋白质尚不清楚。近期,加州大学圣地亚哥分校与拉霍亚免疫学研究所的一项联合研究发现,HSCs优先将错误折叠的蛋白质运输到聚集体中,并依赖聚集体自噬在体内维持蛋白质稳态。研究成果发表在《Cell Stem Cell》期刊,标题为“Hematopoietic stem ...
Biomedical engineer Jonathan Butcher never thought he could learn how to fix cardiac malformations by analyzing brain cancer or plants. But that’s exactly what he and a team of Cornell researchers an...
情绪状态会影响身体的生理机能。例如,焦虑会导致心脏跳动加快,这是一个自上而下的过程。然而,心率加快是否会反过来诱发焦虑反应尚不清楚。美国斯坦福大学研究团队通过小鼠试验,发现情感状态受心率的影响。该研究成果于近日发表在《Nature》杂志上,题为:Cardiogenic control of affective behavioural state。

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