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Suppression of steroid receptor-chromatin interaction by inhibitors present in ammonium sulfate-fractionated rat testicular androgen receptor preparations
steroid receptor-chromatin interaction inhibitors present ammonium sulfate-fractionated rat
2009/2/23
Tritiated androgen receptor complex was partially purified by ammonium sulfate precipitation at 15 to 37% saturation from rat testicular or prostatic cytosols. A greater amount of prostatic tritiate...
Reversal of testicular function after prolonged suppression with an LHRH agonist in rhesus monkeys
testicular function prolonged suppression LHRH agonist rhesus monkeys
2009/2/23
Using subcutaneously implanted osmotic pumps, four male rhesus monkeys were continuously infused for 18 months with 100 micrograms/day of [(imBzl)-D-His6-Pro9-NEt]-LHRH (LHRH-A), a potent agonist of...
Stimulation of sperm production by human chorionic gonadotropin after prolonged gonadotropin suppression in normal men
sperm production human chorionic gonadotropin prolonged gonadotropin suppression normal men
2009/2/20
The precise hormonal milieu required for quantitatively normal spermatogenesis in man is unclear. The authors previously have shown that both supraphysiologic dosages of human chorionic gonadotropin...
Prolonged suppression of plasma LH levels in male rats after a single injection of an LH-RH agonist in poly（DL-lactide-co-glycolide）microcapsules
LH-RH agonist biodegradable microcapsules LH PRL rats
2009/2/20
The authors have examined the effects of a subcutaneous injection of the LH-RH agonist D-Trp6-LH-RH formulated in biodegradable poly(DL-lactide-co-glycolide) microcapsules on plasma levels of D-Tr...
Administration of constant low doses of androgens to steers by silastic implant. Suppression of gonadotropins and peripheral conversion of androgens
androgen implants steers gonadotropins peripheral metabolism of androgens
2009/2/20
Yearling Hereford calves approximately 300 kg in weight were castrated and assigned to one of six treatment groups receiving subcutaneous implants (3 implants, 0.5 cm diameter by 10 cm length, 10% s...
Effects of an LHRH agonist analog upon sexual function in male dogs. Suppression, reversibility, and effect of testosterone replacement
LHRH agonists D-Na!(2)6-LHRH spermatogenesis
2009/2/20
Male beagle dogs were injected once daily with 10 micrograms/kg of [6-D-(2-naphthyl)alanine]-LHRH (D-Nal(2)6-LHRH), a potent LHRH agonist, for periods up to 42 days, with recovery periods up to 172 ...
Suppression of the proliferative response of the seminal vesicles to testosterone by inhibitors of prostaglandin synthesis. Testosterone, indomethacin, and proliferation in seminal vesicles
seminal vesicles testosterone prostaglandin synthesis
2009/2/19
Effects of indomethacin (1.25 mg/kg) and aspirin (20 mg/kg) on testosterone-induced (0.25 mg/rat), and of indomethacin on dihydrotestosterone-induced (0.25 mg/rat) mitotic activity of the seminal ...
Testicular and Adrenal Steroid Profiles During PRL Suppression by Lisuride in Men
lisuride testis hCG steroids prolactin
2009/2/18
Lisuride hydrogen maleate is known to reduce serum prolactin (PRL) in rodents and humans. The authors have examined the effects of short-term lisuride administration on testicular and adrenal func...
Suppression of growth hormone does not affect ongoing spermatogenesis in rats
Suppression of growth hormone ongoing spermatogenesis rats
2009/2/18
Recent evidence suggests that growth hormone (GH) may enhance physiologic processes, such as spermatogenesis, in addition to causing classical anabolic effects. We have previously shown that testost...
Follicle-stimulating hormone is required for the initial phase of spermatogenic restoration in adult rats following gonadotropin suppression
Testosterone germ cell spermatogonia stereology
2009/2/18
The role of follicle-stimulating hormone (FSH) in adult rat spermatogenesis is unclear. Although exogenous testosterone (T) restores spermatogenesis following gonadotropin-releasing hormone (GnRH)...
Suppression and recovery of spermatogenesis following spinal cord injury in the rat
Sertoli cells Leydig cells testosterone follicle stimulating hormone
2009/2/17
Recently, we reported that changes in spermatogenesis in adult rats during acute phase (within 2 weeks) of spinal cord injury (SCI) were associated with a suppression of pituitary-testis hormone a...
Suppression of spermatogenesis by low-level glycerol treatment
spermatogenesis low-level glycerol treatment
2009/2/12
Previous studies have shown that a single intratesticular injection with 70% glycerol results in rapid and long-term suppression of spermatogenesis. Because of the extensive testicular damage in the...
Comparative effects of two different delivery systems on gonadotropin-releasing hormone（GnRH） antagonist-induced suppression of gonadotropins and testosterone in man
GnRH antagonists luteinizing hormone (LH)
2009/2/12
The Nal-Glu gonadotropin-releasing hormone (GnRH) antagonist, when given in daily subcutaneous (SC) doses of 5 mg or higher, maximally suppresses serum luteinizing hormone (LH) and follicle-stimul...
Recovery of pituitary-gonadal function in male rats after long-term suppression induced by a single injection of microcapsules of LH-RH antagonist cetrorelix（SB-75）
Reversible gonadal inhibition cancer contraception
2009/2/12
The clinical utility of luteinizing hormone-releasing hormone (LH-RH) analogs can be greatly enhanced by a sustained delivery system, which could maintain elevated peptide levels in the blood for ...
Suppression of androgen action and the induction of gross abnormalities of the reproductive tract in male rats treated neonatally with diethylstilbestrol
androgen action gross abnormalities reproductive tract male rats diethylstilbestrol
2008/12/26
This study evaluated whether androgen action is altered in rats treated neonatally with diethylstilbestrol (DES) at a dose that induced reproductive tract abnormalities. Rats were treated on alterna...