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Acute effects and long-term sequelae of 1,3-dinitrobenzene on male reproduction in the rat. II. Quantitative and qualitative histopathology of the testis
1,3-dinitrobenzene male reproduction rat
2009/2/23
This study determined the quantitative and qualitative histopathologic effects of a single oral dose of 1,3-dinitrobenzene (48 mg/kg) on the rat testis from 1 to 175 days postexposure. The testis was ...
Acute effects and long-term sequelae of 1,3-dinitrobenzene on male reproduction in the rat. I. Sperm quality, quantity, and fertilizing ability
long-term sequelae 1,3-dinitrobenzene male reproduction rat
2009/2/23
Groups of eight adult male rats were given a single oral dose of 0 or 48 mg/kg of 1,3-dinitrobenzene and sacrificed at 1, 2, 4, 8, 16, 24, 32, 72, and 175 days posttreatment. The groups killed at 17...
The effect of long-term opiate antagonist administration to pubertal boys
Puberty opiate control of gonadotropins
2009/2/23
To test further the hypothesis that opiatergic pathways controlling gonadotropin production may be functional during early to mid adolescence, nine pubertal boys with bone ages ranging from 10 to 15...
Reversibility of long-term effects of GnRH agonist administration on testicular histology and sperm production in the nonhuman primate
GnRH agonist LH testosterone testis morphology electron microscopy monkeys
2009/2/23
The present investigation evaluates the long-term effects of GnRH agonist treatment on testicular histology, sperm production and the subsequent recovery of these parameters. Four adult rhesus monke...
Repair of experimental varicoceles in the rat. Long-term effects on testicular blood flow and temperature and cauda epididymidal sperm concentration and motility
varicocele varicocele repair rat testis
2009/2/23
The effects of varicocele and varicocele repair on testicular blood flow, temperature, sperm counts, and sperm motility were assessed in adult male rats. The duration of the experimental varicocele ...
Testosterone levels after bromocriptine treatment in patients undergoing long-term hemodialysis
impotence bromocriptine hyperprolactinemia
2009/2/20
Seventeen out of 34 male patients undergoing long-term hemodialysis had increased basal plasma prolactin levels (mean = 1344 +/- 1158.76 mU/L). Seven of these 17 patients having the greatest degre...
Inability of continuous long-term administration of D-Nal（2）6-LHRH to abolish fertility in male rats
D-Nal(2)6-LHRH fertility male rats
2009/2/19
A highly potent agonist of LHRH, [6-D-(2-naphthyl)-alanine]-LHRH, was administered chronically for 12 weeks to adult male rats by repetitive implantation of pellets, and its effects upon mating, fer...
Inhibition of Spermatogenesis and Steroidogenesis During Long-Term Treatment with hCG in the Rat
hCG spermatogenesis steroidogenesis
2009/2/19
The effects of chronic treatment with hCG (100 I.U.s.c. every second day) on testicular morphology, LH receptor levels and concentration of steroid intermediates of the 4 and 5 biosynthetic pathwa...
The loss of alpha-adrenergic effect during the erectile response in the long-term diabetic rat
Diabetic rats erectile response nitroglycerin phenylephrine
2009/2/17
The present study was designed to investigate the effect of long-term, streptozotocin-induced diabetes on the erectile response in the laboratory rat. Mean arterial blood pressure (MAP) and intracav...
Expression of 140-kDa neural cell adhesion molecule in developing testes in vivo and in long-term Sertoli cell-gonocyte cocultures
Testicular development cell adhesion NCAM immunostaining
2009/2/17
The basis for cell-cell adhesion in the seminiferous epithelium of the developing testis is doubtless critical in supporting events that are essential for the onset and maintenance of normal sperm...
Hormonal regulation of spermatogenesis in the hypophysectomized rat: quantitation of germ-cell population and effect of elimination of residual testosterone after long-term hypophysectomy
Testis germ cells androgen morphometry
2009/2/17
Spermatogenesis continues after long-term hypophysectomy (Hx), but massive cell degeneration prevents seminiferous tubules from attaining the full complement of cells. One objective of this study ...
A possible decline in sperm counts in men and its potential relation to exposure to environmental contaminants are subjects of a broad discussion. Whereas data for human research in this area are ...
Effects of long-term psychological stress on sexual behavior and brain catecholamine levels
Psychological stress sexual behavior Catecholamines
2009/2/16
The effects of long-term psychological stress on sexual behavior and brain catecholamines were investigated in rats. Stress was applied using the communication box developed by Ogawa and Kuwabara ...
Long-term alterations in the permeability of the blood-testis barrier following a single intratesticular injection of dilute aqueous glycerol
Blood-testis barrier permeability glycerol seminiferous tubules Sertoli cells
2009/2/12
The mechanism whereby glycerol exerts its antispermatogenic action is not known. The objective of this study was to determine, with the use of [3H]inulin and [125I]albumin by in vivo and in vitro ...
Recovery of pituitary-gonadal function in male rats after long-term suppression induced by a single injection of microcapsules of LH-RH antagonist cetrorelix（SB-75）
Reversible gonadal inhibition cancer contraception
2009/2/12
The clinical utility of luteinizing hormone-releasing hormone (LH-RH) analogs can be greatly enhanced by a sustained delivery system, which could maintain elevated peptide levels in the blood for ...