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Is Certolizumab Pegol Safe and Effective in the Treatment of Patients with Moderate to Severe Crohn’s Disease? A Meta-analysis of Controlled Clinical Trials
Meta-analysis Certolizumab Pegol Crohn’s Disease
2015/10/8
Background: Tumor necrosis factor-α (TNF-α) antibodies are currently used in patients with moderate to severe Crohn’s disease (CD) who are unresponsive to conventional therapies. Certolizumab pegol (C...
Prevalence of Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis in Patients with Pulmonary Tuberculosis in Zahedan,Southeastern Iran
Prevalence Multidrug-Resistant Extensively Drug-Resistant Tuberculosis Pulmonary Tuberculosis Zahedan Southeastern Iran
2015/9/25
Tuberculosis (TB) is responsible for a large portion of morbidity and mortality worldwide. According to WHO report, tuberculosis is responsible for at least 2 million deaths per year, so 90% of these ...
Evaluation of phenytoin pharmacokinetics in neurotrauma patients
Neurotrauma Pharmacokinetic Free fraction Neurotrauma
2010/4/2
Previous studies have suggested that drug metabolism may be altered in patients with severe neurotrauma. The purpose of this prospective study was to observe the alteration of phenytoin pharmacokineti...
The relationship between pharmacokinetic variables and pharmacodynamic profiles of bolus versus continuous infusion of furosemide in critically ill patients
Furosemide Pharmacokinetics Pharmacodynamic Bolus Infusion
2010/1/5
In this investigation, the pharmacokinetic variables of continuous infusion and intermittent bolus injection of furosemide and the possible relationship between its pharmacokinetic characteristics and...
Variation in the visfatin gene may alter the required dosage of oral antidiabetic agents in type 2 diabetic patients
Visfatin Genotype Antidiabetic agents HOMA QUICKI Type 2 diabetes
2009/11/24
Background: Treatment of diabetes with oral antidiabetic agents is accompanied by considerable variability in pharmacokinetics and clinical efficacy. Genetic factors may contribute to individual diffe...
Randomized, Blinded Trial Comparing Enoxaparin with Unfractionated Heparin in Patients Undergoing Contemporary Percutaneous Coronary Intervention
Enoxaparin Low molecular weight heparin Unfractionated heparin Percutaneous coronary intervention
2010/4/19
Background: This study was designed to examine a unique and low dose use of intravenous enoxaparin in elective percutaneous coronary intervention (PCI) that would be applicable to an unselected popula...
A COMPARISON BETWEEN FLUVASTATIN AND LOVASTATIN EFFECTS IN IRANIAN PATIENTS WITH HYPERCHOLESTEROLEMIA
Fluvastatin. lovastatin lovastatin fluvastatin
2010/5/7
The aim of this study was to determine the effect of lovastatin and fluvastatin compared with placebo in patients with high levels of total cholesterol and low density lipoprotein cholesterol (LDL - C...