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动脉硬化在慢性肾病患者中普遍存在,其发生率和严重程度与心血管危险因素密切相关,包括年龄、高血压、糖尿病和高脂血症等。细胞外基质(ECM)刚度可影响血管平滑肌细胞(VSMCs)的表型和行为。ECM硬化会导致VSMC过度增殖、迁移,并从收缩表型向合成表型转化。然而,细胞是如何感知ECM刚度的改变,并将力学信号转化成生物学信号,这一问题仍有待深入研究。
2022年11年10日,北京大学基础医学院生理学与病理生理学系孔炜教授与孙金鹏教授合作在国际知名心血管杂志《Circulation Research》上在线发表了题为“Nidogen-2 is a Novel Endogenous Ligand of LGR4 to Inhibit Vascular Calcification”的研究论文,揭示了细胞外基质蛋白Nidogen-2作为LGR4的一种新...
天津医科大学基础医学院免疫学系刘喆教授课题组最近报道了淋巴细胞特异性转录因子Spi-B在肺癌早期转移中的作用和相关机制,论文于2017年7月28日发表于国际肿瘤学领域权威期刊《Cancer research》(2016年影响因子9.122,5年影响因子9.826),题目为“Spi-B-mediated Silencing of Claudin-2 Promotes Early Disseminat...
Protein translation is one of the most fundamental and important biological processes, involving numerous cellular components and energy. Although this process has been intensively studied for several...
Cartilage has two major functions in vertebrates. Growth plate cartilage provides a transient template for the majority of our bones and controls the growth of the endochondral skeleton. Articular car...
In 2017 the Gordon Research Conference on Epithelial Differentiation and Keratinization will return to Italy's beautiful Tuscany with close by old and charming villages such as Luca and the very comfo...
There is likely no greater hot-button topic in biomedical and clinical research today than discussions surrounding the utility of active chemicals found in marijuana and how they interact within the b...
天津医科大学基础医学院生理与病理生理学系艾玎教授最近报道了雷帕霉素复合物1在动脉粥样硬化中的作用及其机制,论文于2014年5月发表于心血管领域的权威杂志《Circulation Research》(2013年影响因子11.089,5年影响因子10.759),题目为“Disruption of Mammalian Target of Rapamycin Complex 1 in Macrophage...
IMB researchers took out two of the four awards on offer at the recent Queensland Health and Medical Research Awards. Dr Richard Clark won Senior Researcher of the Year for his work on developing a me...
After giving a brief account about the history of the special program, the objectives and scope of the special program have been discussed and the Iranian scientists and institutes for research and tr...
After mentioning the main differences between malaria control and malaria eradication, it is suggested that all anti–malaria activities in Iran should be renamed as malaria control. Applied research i...
A donation of equipment from Intel to Arizona State University will put sophisticated technology to an entirely new use that could result in earlier, less costly diagnosis of disease. A long-standing ...
Profile of the Nagasaki University Kenya Research Station and Activities.

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