搜索结果: 1-9 共查到“医学遗传学 cancer”相关记录9条 . 查询时间(0.06 秒)
2017癌症遗传学和表观遗传学戈登学术会议（The 2017 Gordon Research Conference on Cancer Genetics & Epigenetics）
Cancer Genetics epigenetic regulators
2017/1/14
There has been increasing awareness of the interplay between mutations and epimutations in driving the initiation and progression of cancer. Specific genetic mutations of epigenetic regulators may cau...
Expression of Testis Specific Genes TSGA10,TEX101 and ODF3 in Breast Cancer
Testis Gene TSGA10 TEX101 ODF3 Breast Cancer
2015/9/28
Background: Breast cancer is the most common malignancy in women around the world so finding new biomarkers for early detection and also study on molecular aspects of breast cancer is valuable. Cancer...
Molecular genetic,diagnosis,prevention and gene therapy in prostatic cancer: review article
Molecular genetic diagnosis prevention gene therapy prostate cancer
2009/12/15
The prostate is a small gland located below the bladder and upper part of the urethra. In developed countries prostate cancer is the second common cancer (after skin cancer), and also the second leadi...
Genetic Polymorphisms in Steroid Hormone Metabolizing Enzymes in Human Breast Cancer
Breast cancer Genetic polymorphism Steroid hormone metabolism
2009/6/26
Epidemiologic studies indicate that most risk factors for breast cancer are related to reproductive and hormonal factors. The evaluation of associations between breast cancer risk and genetic polymorp...
A Preliminary Study of DNA Damage in Peripheral Lymphocytes from Lung Cancer Patients and Healthy Subjects
Comet assay DNA damage Lung cancer Lymphocyte
2009/6/24
A pilot study was undertaken to investigate the differences in oxidative DNA damage and 2-h DNA repair in peripheral lymphocytes between lung cancer patients and healthy subjects. Twenty-four lung ca...
南京汉族群体肺癌易感性相关基因的研究Studies of the Genes Related to Lung Cancer Susceptibility in Nanjing Han Population, China
肺癌 代谢酶基因 多态性 遗传易感性
2008/1/8
摘要
为了探讨南京汉族群体肺癌易感性相关基因，我们采用1:1病例对照研究方法，以PCR—RFLP技术检测了152对肺癌和健康对照的CYP1A1、CYP2E1、GSTM1、GSTT1、GSTP1、mEH和NQO1基因的基因型并分析其与肺癌的相关性。结果发现携带CYP1A1突变基因型（wt/mt和mt/mt）的个体明显增加患肺鳞癌的风险(OR=2.31,95%CI=1.23-4.36)；GSTT1（...
山东临朐胃癌高发人群和北京人群Lewis血型抗原相关SE基因多态性分析Analysis of Polymorphisms on Lewis Blood Group Antigen Related SE Gene in the Populations in Shandong with High-risk of Gastric Cancer and Beijing
胃癌 Lewis血型抗原 SECRETOR基因 基因多态性
2007/12/30
摘要为探讨宿主的遗传背景和幽门螺杆菌（Helicobacter pylori,H.pylori）相关胃癌的易感性之间的关系，本文采用PCR产物直接测序和PCR-RFLP的方法，检测142例山东临朐县胃癌高发人群个体（包括69例癌症患者和73例非癌个体）和93例北京正常对照个体SE基因多态性的分布特点。结果显示：sew/sew基因型在山东非癌个体和北京人群之间的分布差异具有统计学意义（P＜0.01,...
山东胃癌高低发人群Lewis基因多态性分析Analysis of Lewis Gene Polymorphism in High and Low Incidence Area of Gastric Cancer in Shandong Province
胃癌 高低发人群 Lewis基因多态性
2007/12/30
摘要应用PCR产物直接测序的方法，检测山东省胃癌高发的临朐人群和低发的苍山人群中Lewis基因多态性T59G的分布,旨在探讨山东临朐和苍山地区胃癌发病率显著不同的内在原因，为阐明临朐地区胃癌高发的机制提供实验依据。结果表明,T59G突变个体在临朐和苍山人群中的分布频率分别为34.5%和31.6%，差别无统计学意义，P＞0.05,OR为1.14 （95% CI,0.59~2.19）。提示就此点突变而...
摘要
为探讨一种快速、简便、可靠的胃癌微卫星不稳定性（MSI）检测方法，变性聚丙烯酰胺凝胶电泳-银染法检测28例胃癌12个微卫星位点(D1S548、D1S552、D5S346、TP53、IGFIIR(G)8、IGFIIR(CT)5、TGFßRII(GT)3、TGFßRII(A)10、hMSH3(A)8、hMSH6(G)8、BAX(G)8和Bat26），DHPLC柱温50℃...