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Targeting acute phosphatase PTEN inhibition and investigation of a novel combination treatment with Schwann cell transplantation to promote spinal cord injury repair in rats
PTEN mTOR Schwann cells transplantation neuroprotection
2015/5/21
Human traumatic spinal cord injuries (SCI) are primarily incomplete contusion or compression injuries at the cervical spinal level, causing immediate local tissue damage and a range of potential funct...
In vitro inhibition of human erythrocyte Acetylcholinesterase activity by Zinc and Mercury
Acetylcholinesterase Human erythrocyte
2010/1/6
The effects of zinc and mercury on human erythrocyte acetylcholinestrase activity were studied. Blood used in this study was obtained from 24 apparently healthy individuals and after hemolysation, was...
Investigation of the Inhibition Effects of Some Antibiotics on Human Erythrocyte Carbonic Anhydrase Isozymes
Carbonic anhydrase isozymes antibiotics inhibition
2009/7/2
In this study, the in vitro effects of some antibiotics on carbonic anhydrase (CA) isozymes have been investigated. Human erythrocyte CA-I and CA-II isozymes were separately purified by affinity chrom...
Histological Changes in the Rat Thoracic Aorta after Chronic Nitric Oxide Synthase Inhibition
thoracic aorta nitric oxide L-NAME rat light microscopy
2009/6/24
The objective of this study was to determine the morphological effects of chronic nitric oxide (NO) inhibition on the thoracic aorta of Wistar rats. Fifteen male Wistar Albino rats were divided into t...
Reversal of Endotoxin-Induced Hypotension by Inhibition of Inducible Nitric Oxide Synthase Activity is Associated with Improved Oxidative Status in Rat Heart,Aorta and Mesenteric Artery
Rat endotoxin hypotension inducible nitric oxide synthase lipid peroxidation
2009/6/19
Overproduction of reactive oxygen and nitrogen species leads to oxidative stress and decreased total antioxidant capacity, which is responsible for high mortality from several diseases such as endotox...
Adjuncts (Tramadol and Magnesium) Potentiate Impulse Inhibition by a Local Anaesthetic in Isolated Frog Siatic Nerves?
Bupivacaine magnesium tramadol compound nerve action potential frog sciatic nerve
2009/6/19
Aim: In clinical use, the addition of adjuncts (magnesium or tramadol) to local anesthetic agents is used for different reasons. However, reports about the effect of magnesium plus bupivacaine and of ...
IN VIVO HEMATOPOIETIC CELL ENGRAFTMENT IS MODULATED BY DPPIV/CD26 INHIBITION AND RHEB2 OVEREXPRESSION
Hematopoiesisen Progenitor cells mTOR
2015/5/21
Hematopoietic cell transplantation (HCT) is an important modality used to treat patients with hematologic diseases and malignancies. A better understanding of the biological processes controlling hema...
Aging Exacerbates Restraint Stress-Induced Inhibition of Antigen-Specific Antibody Production in Mice
aged mouse immunosuppression phospholipase A2 restraint stress specific antibody
2010/11/16
Background: We have recently found that exposure to acute restraint stress suppresses antigen-specific antibody production, including IgE, in a murine model of allergic rhinitis. Although age-related ...
STUDY ON GLUTATHIONE S-TRANSFERASE INHIBITION ASSAY BY TRICLABENDAZOLE ON FASCIOLA spp
Glutathione S-transferase Fasciola triclabendazole
2010/4/12
Glutathione S-transferase (GST) represents the major class of detoxification enzymes from helminth parasites such as Fasciola hepatica and F. gigantica and it is a candidate for chemotherapeutic and v...
Inhibition of nasal mucosal eosinophils after immunotherapy is associated with a decrease in interleukin-13 mRNA and vascular cell adhesion molecule-1 expression
adhesion molecule allergic rhinitis apoptosis immunotherapy interleukin-13
2010/11/22
Analysis of the clinical data confirmed that the proportion of patients who showed greater than 60% improvement in symptoms (47 and 15%) and in rescue medication (79 and 10%) were significant for the ...
INHIBITION OF TRYPANOSOMA CRUZI GROWTH IN MAMMALIAN CELLS BY NIMODIPINE, WITH LOW CYTOTOXICITY TO HOST CELLS
Trypanosoma cruzi calcium antagonist nimodipine
2010/12/10
An in vitro infection system of Trypanosoma cruzi and HeLa cells was used to measure the anti-T. cruzi activities of various calcium antagonists classified into dihydropyridines, diphenylalkylamines, ...