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中国科学院研究揭示翻译调控型T-box核糖开关折叠与识别tRNA耦联的结构与动态机制（图）
翻译调控 识别 结构 分子动力学
2023/11/21
T-box核糖开关是一类位于革兰氏阳性细菌mRNA的 5'非翻译区的结构元件。它的长度通常在300核苷酸以下，可分为适配体结构域和表达平台结构域。T-box核糖开关通过其适配体结构域识别和结合特定的tRNA，并感知其3'末端的氨酰化状态，引发下游RNA元件构象状态的转变，进而在翻译水平或转录水平调控下游基因的表达。与其他核糖开关一般通过识别小分子代谢物或离子调控基因表达的机制不同，T-box基因表...
When deep learning models are deployed in the real world, perhaps to detect financial fraud from credit card activity or identify cancer in medical images, they are often able to outperform humans.
Unpacking black-box models（图）
黑盒模型 包装 数学框架 机器学习模型
2023/6/20
Modern machine-learning models, such as neural networks, are often referred to as “black boxes” because they are so complex that even the researchers who design them can’t fully understand how they ma...
马来西亚平面设计协会每周举办 Jack In The Box 共享平台，鼓励设计师以及非设计师共同参与，讨论设计想法、创意、观点等，邀请演讲嘉宾进行演讲。如需参加，邮件联系组委会即可。推荐转发，为日后开发马来西亚的成员做准备。
Machine-learning algorithms are often referred to as a “black box.” Once data are put into an algorithm, it’s not always known exactly how the algorithm arrives at its prediction. This can be particul...
采用低温碱性焙烧-热水浸出工艺脱除白银炉电收尘(EPD)中的砷, 主要考察了焙烧过程中碱料比、焙烧温度、焙烧时间对砷浸出率的影响, 并利用响应曲面法的Box-Behnken设计优化工艺参数。结果表明, 3个因素对EPD中砷的浸出率均有影响, 其中焙烧温度对砷浸出率影响最大。结合单因素实验结果及Box-Behnken设计优化后焙烧条件为: 碱料比1.2, 焙烧温度600 ℃, 焙烧时间2 h。优化条...
对自制的聚乙二醇(PEG)修饰的四氧化三铁(Fe3O4)纳米颗粒进行处方优化,并对其体外释药机制进行研究。方法 采用Box-Behnken效应面法优化Fe3O4纳米颗粒的处方;通过测定不同时间点Fe3O4纳米颗粒的粒径考察其常温下物理化学稳定性;利用超声搅拌法制备分别负载盐酸多柔比星、灯盏乙素、氟尿嘧啶3种不同类型药物的Fe3O4纳米颗粒,并采用透析法对Fe3O4纳米颗粒的释药能力进行研究,再应用...
改进后Ray-Box Intersection权系数矩阵的SART+TVM重建算法
联合代数重建 全变差最小化 Ray-BoxIntersection算法 双线性插值算法 权系数矩阵
2016/7/28
针对均匀采样稀疏型重建问题，研究了Ray-Box Intersection和传统的双线性插值两种权系数矩阵计算方法。对Ray-Box Intersection算法的逻辑漏洞进行了改进，利用直线生成法并结合射线斜率和像素位置关系提出了改进算法。该算法利用代数关系求得射线穿过重建区域的起点和终点，然后取不大于其坐标的最大整数，最后采用直线生成法，依据射线斜率沿X或Y方向得到该条射线在投影区域内经过的所...
Barriers to Black-Box Constructions of Traitor Tracing Systems
two-party computation Secure Multiparty Computation
2015/12/21
Reducibility between different cryptographic primitives is a fundamental problem in modern
cryptography. As one of the primitives, traitor tracing systems help content distributors recover
the ident...
Development of Miniature Full Flow and Model Pipeline Probes for Testing of Box Core Samples of Surficial Seabed Sediments
intact and remolded undrained shear strength t-bar and ball toroid and model pipeline testing
2014/10/31
The box corer is a relatively new tool used in the geotechnical community for collection of soft seabed sediments. Miniature full flow and model pipeline probes were developed as tools to characterize...
Box-Behnken设计-效应面法优化连钱草多糖提取工艺
连钱草 Box-Behnken设计 效应面法 多糖 提取
2016/6/29
对连钱草多糖进行提取,并通过单因素及响应面实验对提取的四个因素:p H、液固比、提取温度和提取时间进行了优化。结果表明:当提取工艺为p H7.2、液固比33∶1(m L/g)、提取温度89℃、提取时间160min时,多糖提取率最高,可达3.40%±0.05%,与理论值3.39%接近。此研究为连钱草多糖的进一步开发和利用提供了理论依据。
Box-Behnken法研究底水油藏直井底水锥进影响因素
底水锥进 数值模拟 Box-Behnken试验设计
2014/7/29
底水锥进是影响底水油藏开发效果的重要因素。用某实际油藏资料建立了底水油藏的数值模型，在综合考虑各种影响底水锥进的单因素基础上，设计底水锥进影响因素的无因次参数群，应用数值模拟计算的累积产油、产水和产液量回归俞启泰水驱特征曲线，以求得反映直井见水特征的参数b（水驱特征曲线斜率）。以参数b 为研究对象，运用Box-Behnken 试验设计，通过曲面反应法研究不同因素对b 值的影响，并得出各影响因素对底...
The impacts of big box retail on downtown: A case study of Target in Davis, California
big box retail on downtown Target in Davis California
2014/5/8
While big box stores are appealing for their low prices and convenience, they are also widely criticized for their potentially deleterious impacts on communities. Controversy over big box retail often...
Existing state and features of relatively minor industrial accidents related to the use of roll box pallets (RBPs)
Existing state features relatively minor industrial accidents related roll box pallets
2013/9/30
Roll box pallets (RBPs) are four-wheeled cages that are used in many industries and contribute to efficient logistics services. However, we found that many work-related injuries to the hands and feet ...