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The Human Genome Project was an ambitious initiative to sequence every piece of human DNA. The project drew together collaborators from research institutions around the world, including MIT's Whitehea...
Johns Hopkins Biologist Leads Team That Unlocks Mystery of Protein Function
Johns Hopkins Biologist Leads Team Unlocks Mystery Protein Function
2017/12/18
What makes the body of a person or any other organism work can for the most part be summed up in a word: proteins.These big molecules carry out almost all processes in living organisms, including movi...
Negative feedback loops help maintain function of mutated proteins
Negative feedback loops maintain function mutated proteins
2016/7/4
Negative feedback is a universal control mechanism that lets a system’s output throttle its input. If an engine revs up, negative feedback tapers its power source. But if the engine slows down, it re-...
The protein complex that holds strands of DNA in compact spools partially disassembles itself to help genes reveal themselves to specialized proteins and enzymes for activation, according to Rice Univ...
Scientists discover the evolutionary link between protein structure and function
Scientists evolutionary link protein structure function
2016/5/31
Proteins are more than a dietary requirement. This diverse set of molecules powers nearly all of the cellular operations in a living organism. Scientists may know the structure of a protein or its fun...
Protein function prediction by integrating sequence, structure and binding affinity information
protein function binding affinity information
2015/5/26
Proteins are nano-machines that work inside every living organism. Functional disruption of one or several proteins is the cause for many diseases. However, the functions for most proteins are yet to ...
STRUCTURE-FUNCTION ANALYSIS OF CXXC FINGER PROTEIN 1
differentiation CXXC finger protein 1 histone methylation
2015/5/25
This dissertation describes structure-function studies of CXXC finger protein 1 (Cfp1), encoded by the CXXC1 gene, in order to determine the functional significance of Cfp1 protein domains and propert...
THE MECHANISMS REGULATING THE TRANSCRIPTION FACTOR ATF5 AND ITS FUNCTION IN THE INTEGRATED STRESS RESPONSE
ATF5 stress uORF
2015/5/25
Phosphorylation of eukaryotic initiation factor 2 (eIF2) is an important mechanism regulating global and gene-specific translation during different environmental stresses. Repressed global translation...
New lab technique simultaneously reveals structure and function of proteins critical in DNA repair
structure and function proteins critical DNA repair
2015/4/29
By combining two highly innovative experimental techniques, scientists at the University of Illinois at Urbana-Champaign have for the first time simultaneously observed the structure and the correlate...
Expression and Function of the PRL Family of Protein Tyrosine Phosphatase
PRL phosphatase PTP4A DSP cancer
2015/5/22
The PRL family of enzymes constitutes a unique class of protein tyrosine phosphatase, consisting of three highly homologous members (PRL-1, PRL-2, and PRL-3). Family member PRL-3 is highly expressed i...