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New method tracking changes in blood vessels could advance brain disease detection（图）
血管变化 脑部疾病 成像技术 神经退行性疾病
2023/6/26
A new imaging technique opens a path toward long-term study of blood vessels in aging brains and could help predict neurodegenerative diseases decades before symptoms begin.
Our brains are charged with the task of directing most of the processes needed for our bodies to function. As such, they consume roughly 20% of our body’s metabolic energy, even while we’re resting.
While neurons and glial cells are by far the most numerous cells in the brain, many other types of cells play important roles. Among those are cerebrovascular cells, which form the blood vessels that ...
2019年1月，宣武医院神经外科张鸿祺教授团队在《BRAIN》（5年IF：11.2）上发表题为"High prevalence of KRAS/BRAF somatic mutations in brain and spinal cord arteriovenous malformations"论文。研究团队利用常见肿瘤相关基因Panel对病变组织进行超深度全外显子测序，发现肿瘤相关通路基因KRA...
Therapeutic brain modulation with targeted large neutral amino acid supplements in the Pah-enu2 phenylketonuria mouse model
phenylketonuria inborn error of metabolism large neutral amino acids mouse model neurotransmitters brain biochemistry treatment
2018/12/18
Background: Phenylketonuria treatment consists mainly of a Phe-restricted diet, which leads to suboptimal neurocognitive and psychosocial outcomes. Supplementation of large neutral amino acids (LNAAs)...
The augmentation of brain thioredoxin-1 expression after severe hypobaric hypoxia by the preconditioning in rats
Hypobaric hypoxia Preconditioning Antioxidants Thioredoxin-1 Immunocytochemistry
2014/3/31
Induction of endogenous antioxidants is one of the key molecular mechanisms of cell resistance to hypoxia/ischemia. The effect of severe
hypoxia on the expression of cytosolic antioxidant thioredoxin...
Induction of Tolerance to Focal Ischemia in Rat Brain: Dissociation Between Cortical Lesioning and Spreading Depression
Rat Brain Cortical Lesioning Spreading Depression
2014/3/31
Cortical application of KCl has previously been
shown to induce tolerance to a subsequent episode of cerebral
ischemia. KCl triggers recurrent episodes of cortical spreading
depression and produces...
Investigation of the subunit compositi on and the pharmacology of the mitochondrial ATP-dependent K + channel in the brain
ATP-dependent potassium channel Ischemic preconditioning Mitochondrial nitric oxide synthase mtNOS Sulfonylurea recepto
2014/3/31
Selective activation of mitoK
AT P
channels can protect the brain or cultured neurons against a variety of anoxic or metabolic challenges.
However, little is known about the subunit composition or ...