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New method tracking changes in blood vessels could advance brain disease detection(图)
血管变化 脑部疾病 成像技术 神经退行性疾病
2023/6/26
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2019年1月,宣武医院神经外科张鸿祺教授团队在《BRAIN》(5年IF:11.2)上发表题为"High prevalence of KRAS/BRAF somatic mutations in brain and spinal cord arteriovenous malformations"论文。研究团队利用常见肿瘤相关基因Panel对病变组织进行超深度全外显子测序,发现肿瘤相关通路基因KRA...
Therapeutic brain modulation with targeted large neutral amino acid supplements in the Pah-enu2 phenylketonuria mouse model
phenylketonuria inborn error of metabolism large neutral amino acids mouse model neurotransmitters brain biochemistry treatment
2018/12/18
Background: Phenylketonuria treatment consists mainly of a Phe-restricted diet, which leads to suboptimal neurocognitive and psychosocial outcomes. Supplementation of large neutral amino acids (LNAAs)...
The augmentation of brain thioredoxin-1 expression after severe hypobaric hypoxia by the preconditioning in rats
Hypobaric hypoxia Preconditioning Antioxidants Thioredoxin-1 Immunocytochemistry
2014/3/31
Induction of endogenous antioxidants is one of the key molecular mechanisms of cell resistance to hypoxia/ischemia. The effect of severe
hypoxia on the expression of cytosolic antioxidant thioredoxin...
Induction of Tolerance to Focal Ischemia in Rat Brain: Dissociation Between Cortical Lesioning and Spreading Depression
Rat Brain Cortical Lesioning Spreading Depression
2014/3/31
Cortical application of KCl has previously been
shown to induce tolerance to a subsequent episode of cerebral
ischemia. KCl triggers recurrent episodes of cortical spreading
depression and produces...
Investigation of the subunit compositi on and the pharmacology of the mitochondrial ATP-dependent K + channel in the brain
ATP-dependent potassium channel Ischemic preconditioning Mitochondrial nitric oxide synthase mtNOS Sulfonylurea recepto
2014/3/31
Selective activation of mitoK
AT P
channels can protect the brain or cultured neurons against a variety of anoxic or metabolic challenges.
However, little is known about the subunit composition or ...