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Testicular steroidogenesis in the aging brown Norway rat
Aging testis steroidogenesis Leydig cell rat
2009/2/12
In seeking an animal model of age-associated changes in the male reproductive tract, we examined the effects of age on the health and testicular steroidogenic activity of the Brown Norway rat, with ...
The effect of aging on the seminiferous epithelium of the brown Norway rat
seminiferous epithelium brown Norway rat
2009/2/12
Aging of the mammalian testis is often accompanied by loss of germ cells and, as a result, decreased daily sperm production. It is currently unknown whether cell loss is the result of aging-related ch...
The effects of normal aging on the response of the pituitary-gonadal axis to chronic clomiphene administration in men
Testes inhibin gonadotropins age
2009/2/7
Serum androgens decline with age in normal men, despite normal or elevated bioactive serum gonadotropins, suggesting that primary testicular dysfunction occurs with aging. The authors further assess...
Sperm structural and motility changes during aging in the Brown Norway rat
Sperm structural motility changes Brown Norway rat
2008/12/26
The Brown Norway rat provides a useful model to study aging of the male reproductive tract because of the selective age-dependent pathological changes that are found in the testis, epididymis, and pro...
Leydig cell aging：steroidogenic acute regulatory protein（StAR）and cholesterol side-chain cleavage enzyme
Leydig cell aging protein（StAR） cholesterol side-chain cleavage enzyme
2008/12/26
Primary points of control in steroidogenesis are the transport of cholesterol from intracellular stores to the inner mitochondrial membrane, and the subsequent conversion of cholesterol to pregnenolon...
Spontaneous hyperplasia of the ventral lobe of the prostate in aging genetically hypertensive rats
Spontaneous hyperplasia ventral lobe prostate aging genetically hypertensive rats
2008/12/25
Recent studies have shown that the prostatic autonomic innervation takes part in its homeostasis and growth. Other works showed that spontaneously hypertensive rats (SHR) show excessive sympathetic ...
Spermatozoa Have Decreased Antioxidant Enzymatic Capacity and Increased Reactive Oxygen Species Production During Aging in the Brown Norway Rat
Oxidative stress epididymis glutathione peroxidase superoxide dismutase reproduction sperm
2008/12/24
As the proportion of aged males attempting to reproduce continues to rise, so does the concern regarding the quality of spermatozoa from aged men. An imbalance between the generation of reacti...
Testosterone Replacement Therapy for Male Aging：ASA Position Statement
Testosterone Replacement Therapy Male Aging ASA Position Statement
2008/12/23
The American Society of Andrology suggests that testosterone replacement therapy in aging men is indicated when both clinical symptoms and signs suggestive of androgen deficiency and decreased testo...
Rho-kinase Inhibition Improves Erectile Function in Aging Male Brown-Norway Rats
Muscle smooth drug effects penis physiology biological aging penile erection
2008/12/23
Physiological aging is a significant risk factor in the on-set of male erectile dysfunction (ED) and an imbalance in factors that modulate cavernosal smooth-muscle tone may play a role in these altere...
Temporal Relationships Among Testosterone Production, Steroidogenic Acute Regulatory Protein (StAR), and P450 Side-Chain Cleavage Enzyme（P450scc）During Leydig Cell Aging
Leydig cell cyclic AMP steroidogenesis Brown Norway rat
2008/12/22
Previous studies have shown that the capacity of Leydig cells from aged (21-24-month-old) Brown Norway rats to produce testosterone is reduced from young (4-month-old) levels, and that this is cor...
Testosterone，Sexuality，and Erectile Function in Aging Men
Testosterone Sexuality Erectile Function Aging Men
2008/12/19
Human aging is associated with many changes, which resemble those seen with deficiencies of sex steroids or growth hormone and with cortisol excess. Among these are decreases in lean body mass (LBM) a...
Cholesterol Transport, Peripheral Benzodiazepine Receptor, and Steroidogenesis in Aging Leydig Cells
Mitochondria steroidogenic acute regulatory protein
2008/12/3
The cellular mechanisms responsible for age-related decline in the ability of Leydig cells to produce testosterone are not yet fully understood. The decline in testosterone production could result fro...
Changes in Hormone Sensitivity in the Ventral Prostate of Aging Sprague-Dawley Rats
Lipofuscin antioxidants stroma age hormone-dependent regression apoptosis
2008/12/3
The adult rat ventral prostate, which has been used extensively as a model for hormone-dependent prostate cancer, is composed of hormone-dependent columnar secretory epithelial cells and a mixture...
Another Piece in the Maddening Puzzle of Declining Steroidogenesis in Aging Leydig Cells
Maddening Puzzle Declining Steroidogenesis Aging Leydig Cells
2008/12/3
Firm evidence for the age-related decrease in testosterone secretion was provided by Hollander and Hollander in 1958, when they determined that spermatic vein testosterone levels were significantl...