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Tumor necrosis factor and interleukin-1 stimulate testosterone secretion in adult male rat Leydig cells in vitro
umor necrosis factor interleukin-1 testis testosterone
2009/2/6
The actions of two cytokines, tumor necrosis factor (TNF) and interleukin-1 (IL-1), on testosterone production by dispersed adult testis cells and purified Leydig cells in culture were studied. In o...
Testosterone release from a subcutaneous, biodegradable microcapsule formulation（Viatrel）in hypogonadal men
Hypogonadism poly-lactide-co-glycolide pharmacokinetics
2008/12/30
Men with hypogonadism require testosterone replacement for optimal health. In the United States, testosterone is currently administered by daily transdermal patches, topical gels or intramuscular in...
Daily testosterone and gonadotropin levels are similar in azoospermic and nonazoospermic normal men administered weekly testosterone: implications for male contraceptive development
Contraception gonadotropins azoospermia
2008/12/29
Weekly intramuscular administration of testosterone esters such as testosterone enanthate (TE) suppresses gonadotropins and spermatogenesis and has been studied as a male contraceptive. For unknown ...
Mullerian inhibiting substance inhibits testosterone synthesis in adult rats
Anti-Mu llerian hormone primary Leydig cells
2008/12/29
Mullerian inhibiting substance (MIS) is a gonadal hormone that causes regression of the Mullerian ducts during male sexual differentiation. Postnatally, MIS inhibits the proliferation and differen...
Atrazine effects on testosterone levels and androgen-dependent reproductive organs in peripubertal male rats
testosterone levels androgen-dependent reproductive organs peripubertal male rats
2008/12/26
Previous studies have reported that atrazine, a widely used herbicide that selectively inhibits photosynthesis in broadleaf and grassy weeds, has adverse effects on reproductive function in the male, ...
Suppression of spermatogenesis with desogestrel and testosterone pellets is not enhanced by addition of finasteride
Suppression of spermatogenesis with desogestrel and testosterone pellets finasteride
2008/12/26
Conversion of testosterone to dihydrotestosterone (DHT) by the action of 5alpha-reductase can amplify androgen action. This may be of particular importance in the presence of low testosterone concentr...
The antigonadotropic action of testosterone but not 7alpha-methyl-19-nortestosterone is attenuated through the 5alpha-reductase pathway in the castrated male rat pituitary gland
antigonadotropic action testosterone 7alpha-methyl-19-nortestosterone 5alpha-reductase castrated male rat pituitary gland
2008/12/25
The enzyme 5alpha-reductase plays a significant role in the prostate to amplify the action of testosterone (T) by converting it to a more potent androgen, dihydrotestosterone (DHT). The role of 5alp...
Exogenous Testosterone Alone or With Finasteride Does Not Improve Measurements of Cognition in Healthy Older Men With Low Serum Testosterone
Aging testosterone replacement memory visual spatial function
2008/12/24
Testosterone (T) levels decline as men age, but it is unclear whether this has an effect on cognition. Some studies indicate that lower T levels are associated with memory loss; thus, maintaining a...
Ghrelin Expression in Human Testis and Serum Testosterone Level
Ghrelin Expression Human Testis Serum Testosterone
2008/12/24
Ghrelin, which is the endogenous ligand for the growth hormone (GH) secretagogue receptor (GHS-R), has been primarily linked to the central neuroendocrine regulation of GH secretion and food i...
Effect of Testosterone on Intracavernous Pressure Elicited With Electrical Stimulation of the Medial Preoptic Area and Cavernous Nerve in Male Rats
MPOA penile erection
2008/12/24
We studied the effects of castration and testosterone (T) replacement on intracavernous pressure (ICP) elicited with electrical stimulation of the medial preoptic area (MPOA) and cavernous nerve (CN) ...
Metastatic Prostate Cancer After Orchiectomy, Radiotherapy, and Testosterone Replacement in a Patient With Bilateral Seminoma
Metastatic Prostate Cancer Orchiectomy Radiotherapy Testosterone Replacement Bilateral Seminoma
2008/12/24
Although its clinical benefits remain unproven and its indications controversial, the popularity of testosterone replacement therapy has grown substantially in recent years, in order to maintain v...
Pharmacokinetics of Testosterone Undecanoate Injected Alone or in Combination With Norethisterone Enanthate in Healthy Men
Azoospermia oligozoospermia male contraception
2008/12/24
Long-acting injectable testosterone undecanoate (TU) is a promising androgen for male hormonal contraception. As a prerequisite for a planned multicenter male contraceptive efficacy study, we studie...
Use of a GnRH Agonist and hCG to Obtain an Index of Testosterone Secretory Capacity in the Koala（Phascolarctos cinereus）
Marsupial hormone stimulation test
2008/12/24
Testosterone secretion in mammals typically occurs in random pulses such that a single blood sample provides limited information on reproductive endocrine status. However, it has been shown in sever...
Dose–Response Relationship Between Testosterone and Erectile Function: Evidence for the Existence of a Critical Threshold
Androgens erection neural NOS phosphodiesterase type 5 prostate
2008/12/24
Androgens play an important role in erectile function. However, the dose–response relationship between plasma testosterone levels and penile erection remains unclear. Intact (sham operated) or bi...
Feedback Inhibition of Gonadotropins by Testosterone in Men With Hypogonadotropic Hypogonadism: Comparison to the Intact Pituitary-Testicular Axis in Primary Hypogonadism
Gonadotropins Men Hypogonadotropic Hypogonadism Intact Pituitary-Testicular Axis Primary Hypogonadism
2008/12/24
Men with hypogonadotropic hypogonadism (HH) due to hypothalamic-pituitary disease present with low serum testosterone levels combined with undetectable, low, or normal gonadotropin levels. Treatment...