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Ultrastructural observations of spermatogenesis in mice resulting from transplantation of mouse spermatogonia
Testis mouse spermatogenesis electron microscopy
2009/2/16
The objective of the present study was to provide a morphological characterization of spermatogenesis following germ cell transplantation into the seminiferous tubular lumen of another mouse. The re...
Differential expression of clusterin in the testis and epididymis of postnatal and germ cell deficient mice
clusterin epididymis postnatal germ cell deficient mice
2009/2/16
Clusterin is found in a wide variety of tissues and is expressed in a number of physiological and pathological contexts. It is expressed constitutively in the adult male reproductive tract, specific...
The effects of recombinant FSH on testosterone-induced spermatogenesis in gonadotrophin-deficient（hpg）mice
Seminiferous tubule testis Sertoli cells FSH testosterone
2009/2/16
In order to clarify the mechanism of synergism between follicle-stimulatory hormone(FSH) and testosterone (T) in the hormonal regulation of spermatogenesis, we studied the effects of recombinant h...
Morphometric study of the gubernaculum in male estrogen receptor mutant mice
ERKO estrogen estrogen receptor cremaster processus vaginalis testis gubemaculum
2009/2/16
To determine role of estrogen receptors in testicular descent, a morphometric study of the testis and structures derived from the gubernaculum was made in sexually mature male mice having an estro...
The contraceptive effects of etoprine on male mice and rats
Etoprine male contraception spermatogenesis dihydrofolate reductase
2009/2/13
We had previously found that 2,4-diaminopyrimidines affected spermatogenesis, possibly through the inhibition of testicular dihydrofolate reductase (DHFR). The current study examined the effects of ...
Human chorionic gonadotropin but not the calcitonin gene-related peptide induces postnatal testicular descent in mice
Cryptorchidism mechanisms androgens paracnne factors gonadotropins testes
2009/2/13
The androgen-regulated paracrine factor, calcitonin gene-related peptide (CGRP), has been proposed as a possible mediator of testicular descent. This peptide has been found to increase rhythmic co...
Testosterone feedback on gonadotropin secretion and gene expression in transgenic mice expressing human growth hormone gene
Luteinizing hormone follicle-stimulating hormone
2009/2/12
To determine the effects of testosterone on the regulation of gonadotropins in metallothionein-1/human growth hormone (MT/hGH) transgenic mice, basal and gonadotropin-releasing hormone (GnRH)-stim...
The effect of ketoconazole on endocrine and reproductive parameters in male mice and rats
Ketoconazole male fertility male contraception testosterone corticosterone
2009/2/10
Ketoconazole has been shown to reduce steroidogenesis by inhibiting the cytochrome P-450 enzymes in these pathways. This finding, along with the observation that the compound reduces sperm motili...
Impairment of spermatogenesis in transgenic mice with selective overexpression of Bcl-2 in the somatic cells of the testis
Apoptosis Bax Sertoli cell Leydig cell endocrine dysfunction
2008/12/29
To explore the functional role of Bcl-2 in germ cell development, transgenic mice carrying 6 kilobases of the inhibin-alpha promoter were generated to express human bcl-2 gene product in the gona...
Expression of Notch pathway components in spermatogonia and Sertoli cells of neonatal mice
Cell fate delta jagged presenilin spermatogenesis
2008/12/29
Members of the Notch gene family have been shown to play an important role in the control of cell fate in many developmental systems. We hypothesized that the fate of the male germ line stem cells m...
Characterization of the fertility of male aromatase knockout mice
Estrogen spermatogenesis sexual behavior
2008/12/29
Previous studies employing the male aromatase knockout (ArKO) mouse have indicated that local expression of estrogens appears to be important for the progression of spermatogenesis. In the absence o...
Immortalized testis cell lines from estrogen receptor（ER）alpha knock-out and wild-type mice expressing functional ERalpha or ERbeta
Immortalization HPV E6/E7 in vitro models
2008/12/29
The surprising findings that male mice lacking the estrogen receptor (ER) alpha (alphaERKO) have atrophic testis and are infertile proved that ERalpha is involved in normal testicular function. To o...
Intracavernosal pressure monitoring in mice：responses to electrical stimulation of the cavernous nerve and to intracavernosal drug administration
Intracavernosal pressure monitoring mice electrical stimulation intracavernosal drug administration
2008/12/25
With the development of transgenic mice to evaluate mechanisms of erectile function, it appears particularly advantageous to develop a standardized mouse model of penile erection. The purpose of the...
Morphologic changes in efferent ductules and epididymis in estrogen receptor-alpha knockout mice
Morphologic changes efferent ductules epididymis estrogen receptor-alpha
2008/12/25
Estrogen has been shown to have an important role in fluid reabsorption in efferent ductules of the testis. Our previous study of the estrogen receptor-alpha knockout mouse (ERKO) showed that the ...
Mice Lacking Raf Kinase Inhibitor Protein-1 (RKIP-1) Have Altered Sperm Capacitation and Reduced Reproduction Rates With a Normal Response to Testicular Injury
PEBP testis
2008/12/24
Raf kinase inhibitor protein-1 (RKIP-1) belongs to the phosphatidyl ethanolamine–binding family of proteins (PEBP), which are highly conserved throughout evolution and widely expressed in tissues...