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Functional Insights Into Oncogenic Protein Tyrosine Phosphatases By Mass Spectrometry
Protein Tyrosine Phosphatases Mass Spectrometry
2015/5/25
Phosphatase of Regenerating Liver 3 (PRL3) is suspected to be a causative factor toward cellular metastasis when overexpressed. To date, the molecular basis for PRL3 function remains an enigma, justif...
PROTEIN PHOSPHATASE 2A (PP2A) HOLOENZYMES REGULATE DEATH ASSOCIATED PROTEIN KINASE (DAPK) IN CERAMIDE-INDUCED ANOIKIS
PROTEIN PHOSPHATASE 2A DAPK DEATH ASSOCIATED PROTEIN KINASE
2015/5/22
Modulation of sphingolipid-induced apoptosis is a potential mechanism to enhance the effectiveness of chemotherapeutic drugs. Ceramide is a pleiotropic, sphingolipid produced by cells in response to i...
Death-Associated Protein Kinase Regulates Vascular Smooth Muscle Cell Signaling and Migration
p65 MMP9 atherosclerosis
2015/5/22
Cardiovascular disease is the number one cause of death for Americans. New treatments are needed for serious conditions like atherosclerosis, as it can lead to stroke and heart attack. Many types of c...
The Effects of Pre- and Post-Exercise Whey vs. Casein Protein Consumption on Body Composition and Performance Measures in Collegiate Female Athletes
whey casein protein females body composition performance
2015/5/14
Two of the most popular forms of protein on the market are whey and casein. Both proteins are derived from milk but each protein differs in absorption rate and bioavailability, thus it is possible tha...
The Role of Post-Exercise Nutrient Administration on Muscle Protein Synthesis and Glycogen Synthesis
Protein supplementation carbohydrate supplementation anabolism
2015/5/5
Nutrient administration following an exercise bout vastly affects anabolic processes within the human body, irrespective of exercise mode. Of particular importance are protein and carbohydrates whereb...
History may be the Best Guide for Determining the Athlete’s Dietary Protein Needs
Best Guide Athlete’s Dietary Protein Needs
2015/4/21
I was encouraged to read Dr. Longo and colleagues’ Letter to the Editor entitled “The best athletes in ancient Rome were vegetarian!"(Longo et al., 2008). These writers ask that we rethink the issue o...
Sprint-Interval Training Induces Heat Shock Protein 72 in Rat Skeletal Muscles
Hindlimb treadmill running enzyme activity fiber type shift hypertrophy
2015/3/18
Previous studies have demonstrated that endurance exercise training increases the level of heat shock proteins (HSPs) in skeletal muscles. However, little attention has been drawn to the effects of hi...
Protein - Which is Best?
Sport supplementation ergogenic aid animal protein vegetable protein
2015/3/13
athletes. However, considering the variety of proteins that are available much less is known concerning the benefits of consuming one protein versus another. The purpose of this paper is to identify a...
Regulation of Muscle Glycogen Repletion, Muscle Protein Synthesis and Repair Following Exercise
Carbohydrate nutrients insulin glucose amino acids
2015/3/13
Recovery from prolonged strenuous exercise requires that depleted fuel stores be replenished, that damaged tissue be repaired and that training adaptations be initiated. Critical to these processes ar...
Protein Hydrolysates in Sports and Exercise: A Brief Review
Proteins amino acids protein hydrolysates ergogenic aids sports supplements
2015/3/12
Protein can be hydrolyzed, producing small chains of amino acids called peptides. Several studies have shown that protein hydrolysates containing mostly di- and tripeptides are absorbed more rapidly t...
ACTUAL AND PRESCRIBED ENERGY AND PROTEIN INTAKES FOR VERY LOW BIRTH WEIGHT INFANTS: AN OBSERVATIONAL STUDY
Very Low Birth Weight Infants Protein Nutrition Growth Velocity Infant
2015/1/22
Objectives: To determine (1) whether prescribed and delivered energy and protein intakes during the first two weeks of life met Ziegler’s estimated requirements for Very Low Birth Weight (VLBW) infant...
Role of the Multifunctional DNA Repair and Redox Signaling Protein Ape1/Ref-1 in Cancer and Endothelial Cells: Small-Molecule Inhibition of the Redox Function of Ape1
APE1/Ref-1 redox signaling cancer
2014/12/12
The DNA base excision-repair pathway is responsible for the repair of DNA damage caused by oxidation/alkylation and protects cells against the effects of endogenous and exogenous agents. Removal of th...
Conversion of the Bifunctional 8-oxoguanine/β-δ AP DNA Repair Activities of Drosophila Ribosomal Protein S3 into the Human S3 Monofunctional β- elimination Catalyst Through a Single Amino Acid Change
DNA repair drosophila ribosomal protein s3
2014/12/12
The Drosophila S3 ribosomal protein has important roles in both protein translation and DNA repair. In regards to the latter activity, it has been shown that S3 contains vigorous N-glycosylase activit...
Knockdown of the DNA repair and redox signaling protein Ape1/ Ref-1 blocks ovarian cancer cell and tumor growth
base excision repair APE1/Ref-1 ovarian cancer
2014/12/12
Apurinic endonuclease 1/redox effector factor-1 (Ape1/Ref-1 or Ape1) is an essential protein with two distinct functions. It is a DNA repair enzyme in the base excision repair (BER) pathway and a redu...
FcγR-stimulated activation of the NADPH oxidase: phosphoinositide-binding protein p40phox regulates NADPH oxidase activity after enzyme assembly on the phagosome
NADPH oxidase p40phox
2014/12/12
The phagocyte NADPH oxidase generates superoxide for microbial killing, and includes a membrane-bound flavocytochrome b558 and cytosolic p67phox, p47phox, and p40phox subunits that undergo membrane tr...