搜索结果: 136-150 共查到“理学 HIV”相关记录197条 . 查询时间(0.093 秒)
昆明动物所抗HIV药物研发关键技术建立及应用取得进展
昆明动物所 抗HIV药物
2009/6/25
核糖体失活蛋白(RIPs)抗HIV-1活性研究已有十几年的历史。RIPs类化合物代表了抗HIV/AIDS天然产物或先导化合物发展的一个重要方向。本文从介绍RIPs的酶活性及其抗HIV-1活性入手,对RIPs抗HIV-1的可能机制,从与RIPs酶活性的关系、诱导HIV-1感染细胞的凋亡及相应的信号转导、诱发活性氧的产生,以及对HIV-1整合酶的抑制作用等几个方面做了较详尽的阐述,并对RIPs的结构修...
猕猴模型在HIV疫苗研究中的应用
艾滋病 猴免疫缺陷病毒 人猴嵌合免疫缺陷病毒 疫苗 猕猴 动物模型
2009/6/22
对HIV疫苗的研究一直是国际上艾滋病方面研究的热点和难点。动物模型则为疫苗研究必不可缺少的重要工具,缺乏合适的动物模型很大程度上制约了AIDS疫苗的研究。目前在国际上SIV或SHIV感染的猕猴模型为最常用的AIDS研究模型,受猕猴背景及病毒特性等多种因素的影响,使得以上两种模型在HIV疫苗研究中仍存在一定的局限性。为了更好地发挥猕猴模型在HIV疫苗研究中的巨大潜力,开发理想的AIDS猕猴模型已成为...
稳定表达HIV-1辅助蛋白Rev的THP-1细胞模型的建立和鉴定
Rev THP-1 稳定表达
2009/6/22
Human immunodeficiency virus-1(HIV-1)辅助蛋白在其感染和艾滋病发病过程中起着非常重要的作用。Regulator of expression of virion proteins(Rev)作为HIV-1辅助蛋白之一,可以调节病毒结构蛋白mRNA出核转运和蛋白表达,对于病毒的复制至关重要。为研究Rev蛋白对靶细胞表型和功能的影响,本实验采用电穿孔的方法,将HIV-1...
高效抗HIV-1膜融合多肽C22的光谱学研究
HIV-1 gp41 多肽抑制剂 圆二色谱
2009/5/6
艾滋病已给人类社会和经济带来了巨大影响。文章以HIV-1膜融合糖蛋白gp41的C端序列为参照,设计合成了C22多肽的基因序列,经PCR放大以后,通过pTMHa30-51质粒转导进E.coli BL21 (DE3)中进行表达,纯化后得到了C22多肽,表达产物经SDS-PAGE电泳分析和质谱验证。结果表明:C22多肽具有很好热稳定性,良好的HIV-1入侵细胞抑制活性和水溶性,在实验浓度下对细胞无毒性。...
《细胞》:科学家发现HIV入侵细胞新途径
HIV 入侵细胞 新途径
2009/5/6
桑白皮中抗人爱滋病病毒(HIV)成分研究
桑白皮 黄酮
2009/3/31
从中药桑白皮(Morus alba L.)的根皮中分离到6个成分,它们是:morusin(l),mulberrofuran D(2),kuwanon H(3),mulberrofuran K(4),kuwanon G(5),mulberrofuran G(6);并制备了它们的乙酰化合物和葡萄糖甙;还测定了这些化合物的体外抗人爱滋病病毒(HIV)活性和对人淋巴细胞的细胞毒活性,发现其中黄酮 moru...
This Report Card is one in a series produced by theInternational Planned Parenthood Federation (IPPF),under the umbrella of the Global Coalition on Womenand AIDS, and with the support of the United Na...
This Report Card is one in a series produced by the International PlannedParenthood Federation (IPPF), under the umbrella of the Global Coalitionon Women and AIDS, and with the support of the United N...
Review and strengthen Jamaica's action in the light of the aspectsof the Political Declaration on HIV/AIDS from the 2 June 2006High-Level Meeting (to follow up on UNGASS) that particularlyrelate to HI...
This Report Card is one in a series produced by the International PlannedParenthood Federation (IPPF), under the umbrella of the Global Coalitionon Women and AIDS, and with the support of the United N...
This Report Card is one in a series produced by the InternationalPlanned Parenthood Federation (IPPF), under the umbrella of theGlobal Coalition on Women and AIDS, and with the support of the United N...
This Report Card is one in a series produced by the International PlannedParenthood Federation (IPPF), under the umbrella of the Global Coalitionon Women and AIDS, and with the support of the United N...
This Report Card is one in a series produced by theInternational Planned Parenthood Federation (IPPF), under the umbrella of the Global Coalition on Womenand AIDS, and with the support of the United N...
HIV prevention for girls and young women in the Dominican Republic
HIV AIDS young women Dominican Republic
2014/3/28
This Report Card is one in a series produced by the International PlannedParenthood Federation (IPPF), under the umbrella of the Global Coalition onWomen and AIDS, and with the support of the United N...