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Prion study reveals how abnormal proteins damage nerve cells in the brain
Prion study abnormal proteins damage nerve cells the brain
2017/7/20
A new study has uncovered a molecular mechanism in the prion protein that may explain why nerve cells degenerate in prion diseases such as Creutzfeldt-Jakob disease (CJD).The findings, which appear in...
Computational Potential Energy Minimization Studies on the Prion AGAAAAGA Amyloid Fibril Molecular Structures
Computational Potential Energy Minimization Amyloid Fibril Molecular Structures Biological Physics
2012/5/3
X-ray crystallography, NMR (Nuclear Magnetic Resonance) spectroscopy, and dual polarization interferometry, etc are indeed very powerful tools to determine the 3D structures of proteins (including the...
Computational Studies of the Structural Stability of Rabbit Prion Protein Compared to Human and Mouse Prion Proteins
Neurodegenerative Diseases Prion Diseases Immunity Rabbit Prion Protein Rabbit NMR X-ray and Homology Structures
2011/8/11
Abstract: Prion diseases are invariably fatal and highly infectious neurodegenerative diseases affecting humans and animals. The neurodegenerative diseases such as Creutzfeldt-Jakob disease, variant C...
A novel canonical dual computational approach for prion AGAAAAGA amyloid fibril molecular modeling
Mathematical Canonical Duality Optimization Theory Two-body The-oretical Physics Structural Bioinformatics Technology
2011/10/9
Abstract: Many experimental studies have shown that the prion AGAAAAGA palindrome hydrophobic region (113-120) has amyloid fibril forming properties and plays an important role in prion diseases. Howe...
The nature of the infectious agents: PrP models of resistant species to prion diseases (dog, rabbit and horses)
Prion diseases Immunity Rabbit, dog, and horse prion proteins Molecular dynamics.
2011/9/15
Prion diseases are invariably fatal and highly infectious neurodegenerative diseases affecting humans and animals. The neurodegenerative diseases such as Creutzfeldt-Jakob disease, variant Creutzfeldt...
Atomic-resolution structures of prion AGAAAAGA amyloid fibrils
Amyloid Fibrils Prion AGAAAAGA Palindrome Atomic-resolution Structures
2011/8/31
To the best of the authors knowledge, there is little structural data available on the AGAAAAGA palindrome in the hydrophobic region (113-120) of prion proteins due to the unstable, noncrystalline and...
The Lennard-Jones Potential Minimization Problem for Prion AGAAAAGA Amyloid Fibril Molecular Modeling
Lennard-Jones Potential Minimization Problem, Lennard-Jones Potential Well, van der Waals radii
2011/9/13
The simplified Lennard-Jones (LJ) potential minimization problem is minimize f(x) = 4
N
Xi=1
N
X j=1,jRn,
where τij = (x3i−2−x3j...
The Lennard-Jones Potential Minimization Problem for Prion AGAAAAGA Amyloid Fibril Molecular Modeling
Lennard-Jones Potential Minimization Problem Lennard-Jones Potential Well van der Waals radii
2011/7/26
The Lennard-Jones Potential Minimization Problem for Prion AGAAAAGA Amyloid Fibril Molecular Modeling.
Effective hybrid evolutionary computational algorithms for global optimization and applied to construct prion AGAAAAGA fibril models
Effective hybrid evolutionary computational algorithms global optimization construct prion AGAAAAGA fibril models
2011/3/4
Evolutionary algorithms are parallel computing algorithms and simulated annealing algorithm is a sequential computing algorithm.
Optimal atomic-resolution structures of prion AGAAAAGA amyloid fibrils
Optimal atomic-resolution structures prion AGAAAAGA amyloid fibrils
2011/1/5
To date, there is little structural data available on the AGAAAAGA palindrome in the hydrophobic region (113-120) of prion proteins, although many experimental studies have shown that this region has ...
Effective hybrid evolutionary computational algorithms for global optimization and applied to construct prion AGAAAAGA fibril models
Effective hybrid evolutionary computational algorithms global optimization
2011/1/6
Evolutionary algorithms are parallel computing algorithms and simulated annealing algorithm is a sequential computing algorithm. This paper inserts simulated annealing into evolutionary computations a...
Aptamer-Mediated Chemiluminescence Detection of Prion Protein on a Membrane Using Trimethoxyphenylglyoxal
Aptamer-Mediated Chemiluminescence Detection Prion Protein Membrane Using Trimethoxyphenylglyoxal
2010/9/13
Effective recognition and quantitative analysis of the prion protein are important in drug discovery and diagnosis for prion diseases, such as bovine spongiform encephalopathy and Creutzfeldt-Jakob di...
Regulation of Prion Protein Expression: A Potential Site for Therapeutic Intervention in the Transmissible Spongiform Encephalopathies
Prion Protein Expression Potential Site Therapeutic Intervention
2009/4/20
The Transmissible Spongiform Encephalopathies (TSEs) are a group of rare neurodegenerative diseases, which can be transmitted between members of the same species and possibly across different species....
Oxidative damage of prion protein induced by reactive oxygen species
Oxidative damage prion protein induced reactive oxygen species
2009/4/1
Prion protein (PrP) consists of an amino-terminal domain containing a series of octapeptide repeats with the consensus sequence PHGGGWGQ and a carboxyl-terminal domain composed of three α-helices and ...