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Lnc-TALC有望成为治疗替莫唑胺耐药性的关键靶点（图）
替莫唑胺 胶质母细胞瘤 胶质母细胞瘤 神经外科
2022/5/30
近日，黑龙江省医学科学院神经外科研究所副所长、哈医大二院神经外科主任蒋传路教授团队发现胶质母细胞瘤患者对化疗药物替莫唑胺（TMZ）耐药的机制，并以“Lnc-TALC promotes O6-methylguanine-DNAmethyltransferase expression via regulating the c-Met pathway by competitivelybinding wi...
Nature子刊 ： 哈尔滨医科大学蒋传路等证实lnc-TALC在TMZ抗性的胶质母细胞瘤中的治疗意义（图）
哈尔滨医科大学 蒋传路 lnc-TALC TMZ抗性 胶质母细胞瘤 治疗意义
2019/8/5
胶质母细胞瘤（GBM）是成人中最常见的恶性原发性脑癌，诊断时中位生存期为14.6个月，5年生存率仅为5.5％。这种不良预后是由于手术切除后的治疗抵抗和肿瘤复发，并且这种脑肿瘤的治疗仍然是一个挑战。烷基化药物TMZ常用于脑肿瘤患者，但GBM治疗的主要障碍是对TMZ化疗的耐药性的发展。DNA修复酶O6-甲基鸟嘌呤-DNA甲基转移酶（MGMT）表达在TMZ反应性神经胶质瘤中丢失，并在TMZ抗性胶质瘤中高...
Perineal Talc Use and Risk of Endometrial Cancer in Postmenopausal Women
perineal talc endometrial cancer postmenopausal women
2014/11/6
Endometrial cancer is the most common female reproductive cancer in the United States. Most known risk factors for endometrial cancer are either genetic or related to exposure to estrogens; less is kn...
Generation of talc in the mantle wedge and its role in subduction dynamics in central Mexico
Subduction talc serpentine receiver function mantle wedge P-to-S velocity ratio
2014/4/10
Geophysical evidence shows the presence of low-seismic velocity material at the surface of slabs in subduction zones. In the central Mexican subduction zone this appears as a thin (～4 km) low-velocity...
The reaction talc + forsterite = enstatite + H2O: New experimental results and petrological implications
reaction talc H2O New experimental results
2012/3/30
The reaction talc 1 forsterite 5 enstatite 1 H2O has been investigated between 6 and 20 kbar. Previous high-pressure experimental studies suggested various reaction positions,mostly with positive P - ...
Synthesis of Expandable Fluorine Mica from Talc
Expandable mica Fluorine Intercalation Synthesis Talc
2011/12/30
Expandable fluorine micas were synthesized using talc and Na2SiF6 at 800亱C for 2 hours in air, nitrogen, argon, and under vacuum. Gaseous SiF4, generated from Na2SiF6, and the resultant amorphous sodi...
Electrostatic Potential at the Basal (001) Surface of Talc and Pyrophyllite as Related to Tetrahedral Sheet Distortions
Basal oxygen sheet Electrostatic potential Pyrophyllite Talc Tetrahedral sheet distortion
2012/1/5
Maps of the electrostatic potentials at the basal plane of talc and pyrophyllite, computed using a two-dimensional Ewald lattice-sum, reveal the effects caused by structural distortion of the phyllosi...
Thermal Transformation of Talc as Studied by Electron-Optical Methods
Enstatite Morphology Selected-area electron diffraction Talc Thermal transformation Topotactic relation Transmission electron microscopy
2012/1/9
The thermal decomposition of a fibrous talc was studied by transmission electron microscopy (TEM) and selected-area electron diffraction (SAD). Small changes in the lengths of a and b unit-cell parame...
Weathering of Enstatite to Talc Through a Sequence of Transitional Phases
Biopyribole Enstatite Smectite Talc Transmission electron microscopy Weathering
2011/11/23
Abstract: Orthopyroxene (En85) weathers initially by vacancy diffusion, and through this process hydration occurs and a sequence of biopyriboles develops, culminating in a talc-like layer silicate who...
The crystal structure of a sample of talc from Harford County, Maryland, has been determined by least squares refinement from X-ray diffraction photographs. A triclinic cell with a= 5·293, b = 9·179, ...