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清华大学医学院纪家葵课题组在《eLife》发文报道首次实现人类Sertoli细胞的体外重编程（图）
清华大学医学院 纪家葵 课题组 eLife 实现人类 Sertoli 细胞 体外重编程
2019/12/10
2019年11月11日，清华大学医学院纪家葵课题组在《eLife》杂志在线发表了题为“Induction of Sertoli-like cells from human fibroblasts by NR5A1 and GATA4”的研究论文。该文章首次建立了一套由人类成纤维细胞体外诱导Sertoli细胞的重编程系统，并对获得的 hiSCs 细胞的特性及功能进行了系列验证。在哺乳动物体内，Ser...
Sertoli Cell Tumor in Two Sibs with Testicular Ferminization Syndrome
Department of Pathology,Faculty of Medicine,Akdeniz University,Antalya Department of Surgery,Faculty of Medicine,inonu university,malatya
2009/6/30
TFS or complete androgen insensitivity is a familial inherited form of male pseudohermaphroditism which was described by Morris in 1953 (1-7). The inheritance
is X-linked recessive or sex limited aut...
Ghrelin is expressed in and released from mouse testicular Sertoli TM4 cells
mouse testicular Sertoli TM4 cells
2009/3/3
Using newly developed ghrelin specific radioimmunoassay (RIA) combined with high performance liquid chromatography (HPLC), expression and release of ghrelin/des-n-octanoyl ghrelin in mouse testicula...
The differential effects of the indazole-carboxylic acid derivative, tolnidamine, on Sertoli cell protein secretion
Indazole-carboxylic acids tolnidamine antispermatogenic agents Sertoli cell
2009/2/23
The indazole-carboxylic acid derivative tolnidamine (TOL) has marked antispermatogenic activity in rats. Previous morphological and biochemical studies indicate that Sertoli cells are one of the tar...
Leydig cell and extracellular matrix effects on Sertoli cell function：biochemical and morphologic studies
Leydig cell extracellular matrix Sertoli cell function
2009/2/23
The reciprocal influence between Leydig and Sertoli cells prepared from pig testis were studied by coculture of both types of cells in either plastic dishes or dishes coated with basement membrane...
The action of calcitonin on the TM4 Sertoli cell line and on rat Sertoli cell-enriched cultures
TM4 Sertoli cell line rat Sertoli cell-enriched cultures
2009/2/23
The effects of synthetic salmon calcitonin on primary Sertoli cell-enriched cultures and on an established cell line (TM4 cells, derived from immature mouse Sertoli cells) were studied. Synthetic ...
Estradiol and plasminogen activator secretion by cultured rat Sertoli cells in response to melanocyte-stimulating hormones
Estradiol and plasminogen activator secretion cultured rat Sertoli cells melanocyte-stimulating hormones
2009/2/23
Pro-opiomelanocortin-derived peptides, alpha-MSH and beta-endorphin, are synthesized and secreted by Leydig cells, and are believed to have paracrine effects on Sertoli cells in the testis. Peptid...
Incorporation of gossypol and formation of its protein conjugates in mouse transformed Sertoli（TM4）cells
protein conjugates mouse transformed Sertoli（TM4）cells
2009/2/23
Mitochondria of both mouse transformed Sertoli (TM4) cells and primary-cultured rat and mouse Sertoli cells were shown to be preferentially affected by gossypol (Tanphaichitr et al, 1984). To invest...
Polyamine profiles in rat testis, germ cells and Sertoli cells during testicular maturation
Polyamine profiles rat testis germ cells Sertoli cells
2009/2/23
Polyamine cellular concentrations (putrescine, spermidine and spermine) in the rat testis and testicular cell types were determined by fluorescence spectroscopy of their dansyl derivatives. A met...
Transferrin secretion in response to different modes of FSH stimulation and cycloheximide in superfused Sertoli cell cultures
Transferrin secretion FSH stimulation cycloheximide superfused Sertoli cell cultures
2009/2/23
The influence of different modes of FSH stimulation and cycloheximide on transferrin secretion by rat Sertoli cells was investigated using a superfusion culture system. Sertoli cells from 18-day-old...
Effect of germ cells on vectorial secretion of androgen binding protein and transferrin by immature rat Sertoli cells in vitro
germ cells vectorial secretion androgen binding protein transferrin immature rat Sertoli cells
2009/2/23
The influence of germ cells (greater than 85% pachytene spermatocytes) on vectorial secretion of androgen binding protein (ABP) and transferrin by immature rat Sertoli cells was investigated using t...
Inhibition of ornithine decarboxylase activity by follicle stimulating hormone in primary culture of rat Sertoli cells
ornithine decarboxylase follicle stimulating
2009/2/23
The effect of follicle stimulating hormone on the activity of ornithine decarboxylase (ODC) was determined in primary culture of rat Sertoli cells. Three different FSH preparations (NIH oFSH-S-15, S...
Tonic inhibition of adenylate cyclase in cultured hamster Sertoli cells
cAMP hamster Sertoli cell adenylate cyclase culture pertussis toxin
2009/2/23
Sertoli cells cultured from immature hamsters respond to FSH with a dose-related increase in cAMP accumulation. Pertussis toxin acts synergistically with FSH to stimulate cAMP accumulation. This eff...
Cholinergic inhibition of cAMP accumulation in Sertoli cells cultured from immature hamsters
Sertoli cell cAMP muscarinic receptors FSH hamsters testis
2009/2/23
Acetylcholine inhibits FSH-induced cAMP accumulation in cultured Sertoli cells from immature hamsters. This action of acetylcholine is mimicked by muscarinic cholinergic agonists with a rank order o...
Inhibin production by Sertoli cells during testicular regression in the golden hamster
Inhibin production Sertoli cells testicular regression golden hamster
2009/2/23
The objective of this study was to determine if testicular regression in the hamster results in changes in Sertoli cell function that reflect altered pituitary function. Inhibin-like activity was me...