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Fortification with low amounts of folic acid makes a significant difference in folate status in young women: implications for the prevention of neural tube defects
Neural tube defects folic acid fortification
2016/6/1
Mandatory fortification of grain products with folic
acid was introduced recently in the United States, a policy expected
to result in a mean additional intake of 100 mg/d. One way of predicting
th...
Risk Factors of Neural Tube Defects in Northern Iran
Neural Tube Defects Ethnicity Body Mass Index Nutritional Sciences
2015/10/13
Background:: Neural tube defects (NTDs) including spina bifida and anencephaly are the second most common birth defects with 2.8 per 1000 births in northern Iran.
Neural Tube Defects and 19 bp Deletion Within Intron-1 of Dihydrofolate Reductase Gene
Neural tube defects spina bifida dihydrofolate reductase
2009/6/16
Aims: Dihydrofolate reductase (DHFR) is necessary for the reduction of the ingested folates before they are used in the body metabolism. Thus, the DHFR enzyme has an important role in folate supplemen...
妊娠合并糖尿病诱发胚胎先天性神经管缺陷动物模型的MAP 激酶信号传导机制MAP Kinase Signal Pathway in Hyperglycemia-induced Congenital Neural tube defects
神经管缺陷 糖尿病 激酶 ERK JNK/SAPK RAF-1 动物模型
2008/1/20
摘要
为了揭示妊娠合并糖尿病诱发胚胎先天性神经管缺陷的分子机制，并探讨其有效的防治方法。 实验选用6个实验组的 Sprague-Dawley 大鼠：第1组为常规饲养的正常对照组；第2组尾静脉注射65mg/kg Streptozotocin (STZ) 构建妊娠合并糖尿病、且诱发先天性神经管缺陷的实验组大鼠；第3组为STZ构建的糖尿病、但胚胎不伴有先天性神经管缺陷的大鼠模型；第4、5、6 组为 S...
Neural tube defects associated with maternal periconceptional dietary intake of simple sugars and glycemic index
simple sugars glycemic index
2017/1/4
Maternal diabetes, prepregnancy obesity, hyperinsulinemia, and intakes of sweets have been associated with increased risks of neural tube defects (NTDs). The interdependence of these factors suggests ...
Neural tube defects (NTDs) are among the most prevalent
debilitating birth defects worldwide. By 1992, after a series of trials
and intervention studies, the scientific world was finally convinced
...