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本研究利用体外培养大鼠脑微血管内皮细胞(brain microvascular endothelial cells，BMEC)模型，探讨了血管紧张素(Ang)II对大鼠脑微血管内皮细胞表达E-selectin和VCAM-1的影响及其机制，并评价了新型AT1受体拮抗剂化合物EXP-2528对其的影响。采用RT-PCR和Western blotting分别检测大鼠脑微血管内皮细胞E-选择素(E-sel...
An Angiotensin II (Ang II) Type 1 Receptor Blocker, Telmisartan, Improves Insulin Resistance in KK-Ay Diabetic Mice
telmisartan insulin resistance hypertension diabetes PPAR-γ
2009/4/20
Metabolic syndrome is strongly associated with insulin resistance and consists of a constellation of factors such as hypertension and hyperlipidemia that raise the risk for cardiovascular diseases and...
目的研究依那普利对2型糖尿病大鼠血浆Ang II和AT1受体表达的影响。方法用放射免疫法测定血浆Ang II水平，免疫组化法观察血管和肾脏AT1受体表达。结果糖尿病大鼠血浆Ang II明显高于对照组，应用依那普利后大鼠血浆Ang II明显降低。免疫组化染色发现糖尿病大鼠血管内皮细胞、平滑肌细胞和肾脏AT1受体表达明显增加，依那普利治疗组大鼠血管内皮细胞、平滑肌细胞和肾脏AT1受体表达与正常组接近。...