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Hypodiploidy as a prominent attributor to chromosomal aneuploidy in transgenic rabbit embryos
chromosomal aneuploidy EGFP embryo hFVIII rabbit transgenic
2015/6/5
Transgenic animals play a vital role in basic research, agriculture and pharmaceutical industries. Rabbits have the advantage of other large laboratory species in that they have a short gestation peri...
Causes and consequences of maternal age-related aneuploidy in oocytes: a review
aneuploidy oocyte maternal age meiosis spindle assembly checkpoint
2015/4/17
Although a positive correlation between aneuploidy and maternal age was first reported almost a century ago, the underlying mechanisms remain mostly unknown. Different hypotheses regarding age-related...
Comparison of Conventional Cytogenetic and Fluorescence In Situ Hybridization Results of Prenatal Aneuploidy Screening
Aneuploidy prenatal diagnostic tests FISH conventional cytogenetics
2009/6/17
Background and Aim: Prenatal diagnosis of chromosome abnormalities is usually performed on amniotic fluid samples. Aneuploidy screening by fluorescence in situ hybridization (FISH), although not an al...
The efficacy of quantitative fluorescent-polymerase chain reaction (QF-PCR) in the diagnosis of prenatal aneuploidy
Aneuploidy QF-PCR conventional karyotype analysis
2010/1/11
Aim: To investigate the efficacy of quantitative fluorescent-polymerase chain reaction (QF-PCR) in the diagnosis of aneuploidy. Materials and methods: The study included 40 pregnant women considered t...
The Analysis of Meiotic Segregation Patterns and Aneuploidy in the Spermatozoa of Father and Son With Translocation t（4;5）（p15.1;p12）and the Prediction of the Individual Probability Rate for Unbalanced Progeny at Birth
FISH risk assessment
2008/12/24
Reciprocal chromosomal translocations (RCT) have long been recognized as important etiological factors in reproductive failure. In the present study, the meiotic segregation patterns of the sperm...
Increased Aneuploidy Rate in Sperm With Fragmented DNA as Determined by the Sperm Chromatin Dispersion（SCD）Test and FISH Analysis
Human fragmentation
2008/12/24
Previous studies suggest that sperm DNA fragmentation may be associated with aneuploidy. However, currently available tests have not made it possible to simultaneously perform DNA fragmentatio...
Could Sperm Aneuploidy Rate Determination Be Used as a Predictive Test Before Intracytoplasmic Sperm Injection?
Chromosomal profile fluorescent in situ hybridization spermatozoa
2008/12/23
Chromosome abnormalities in embryos are a major cause of implantation and development failures. Some couples with normal karyotypes have repeated implantation failures after intracytoplasmic sperm...
Primary Flagellar Abnormality Is Associated With an Increased Rate of Spermatozoa Aneuploidy
Chromosome abnormalities FISH flagellum male infertility sperm
2008/12/22
The frequencies of aneuploid and diploid spermatozoa were determined in 3 patients presenting a complete asthenozoospermia due to a primary and specific flagellar anomaly: patients 1 and 2 presented...
Absolute Polymorphic Teratozoospermia in Patients With Oligo-Asthenozoospermia Is Associated With an Elevated Sperm Aneuploidy Rate
Enlarged sperm head fluorescence in situ hybridization male infertility
2008/12/19
Infertile patients with abnormal sperm parameters have an increased sperm aneuploidy rate, despite a normal blood karyotype. The evaluation of sperm chromosome aberrations in patients with teratozoo...
Analysis of Aneuploidy in Spermatozoa From Testicular Biopsies From Men With Nonobstructive Azoospermia
Sperm chromosome analysis male infertility fluorescence in situ hybridization
2008/12/18
Testicular sperm biopsy combined with intracytoplasmic sperm injection (ICSI) allows men with azoospermia the possibility of fathering a child. However, little information exists on the risk of chro...
Aneuploidy and chromosome breakage in swim-up versus unprocessed semen from twenty healthy men
Aneuploidy chromosome breakage unprocessed semen twenty healthy men
2008/12/2
Toxicological and epidemiological studies have investigated several factors that are believed to induce cytogenetic damage in human sperm cells in an effort to estimate heritable risk to future gene...