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内镜下5-Fu化学缓释粒子植入联合替吉奥治疗消化道肿瘤疗效观察
消化道肿瘤 替吉奥 内镜 5氟尿嘧啶裂解
2021/1/12
观察内镜下5-Fu化疗缓释粒子植入联合替吉奥治疗消化道肿瘤临床疗效。方法： 选择2011年3月至2014年3月于我院收治的消化道肿瘤患者70例，根据简单随机分组分为观察组和附属，每组35例。替换患者均行替吉奥治疗，观察组患者在替代的基础上，采用5-Fu缓释颗粒植入治疗。治疗3个月后，比较两组患者的疗效以及生存质量。
明确MALAT1调控miR-1影响胆囊癌（gallbladder carcinoma，GBC）细胞对5-FU敏感性的机制。方法：qRT-PCR检测MALAT1和miR-1在GBC细胞GBC-SD、NOZ和SGC-996中的表达；MTT法和流式细胞术检测正常和5-FU处理的GBC细胞的增殖和凋亡；双荧光素酶报告基因实验检测MALAT1和miR-1的靶向关系。
探讨miR-451通过下调耐药基因MRP表达，调控胃癌对5-Fu耐药的相关机制。方法 采用实时荧光定量PCR检测20对人胃癌组织及癌旁组织和胃癌细胞系中miR-451的相对表达量，根据患者对药物的反应进行分组并检测耐药组以及非耐药组miR-451的表达水平。构建plent-miR-451稳定过表达胃癌细胞系，通过荧光实时定量PCR检测胃癌细胞系miR-451过表达效率，CCK8法检测不同浓度5-F...
观察益气健脾化瘀方协同5-氟尿嘧啶（5-Fu）对小鼠胃癌肺转移的抑制作用，并通过肿瘤相关巨噬细胞(Tumor-associated macrophages，TAMs)表型转化探讨其可能的作用机制。方法 30只615小鼠随机分为空白对照组、模型组、5-Fu组、益气健脾化瘀方(YQJPHY)组、5-Fu+益气健脾化瘀方(5-Fu+YQJPHY)组。除空白对照组外各组小鼠尾静脉注射MFC细胞建立小鼠胃癌...
探讨那可丁（Nos）对人结肠癌5-氟尿嘧啶（5-Fu）耐药株耐药性的影响及其机制。方法 构建人结肠癌耐药株HT-29/5-Fu、LoVo/5-Fu及SW480/5-Fu，MTT法筛选出Nos对各组细胞的半数抑制浓度（IC50），观察细胞形态变化，利用流式细胞仪检测细胞周期及凋亡水平；RT-qPCR及Western blot检测细胞P38表达和激活水平，以及耐药相关蛋白的表达。
探讨miR-195对BEL-7402/5-FU细胞5-氟尿嘧啶药物敏感性的影响。方法采用qRT-PCR检测BEL-7402细胞与BEL-7402/5-FU细胞中miR-195的表达水平。将miR-195质粒载体瞬时转染至BEL-7402/5-FU细胞；MTT检测细胞药物敏感性的改变。结果相比于BEL-7402细胞,miR-195在BEL-7402/5-FU细胞中表达水平下调；miR-195转染组的...
应中科院光化学转换与功能材料重点实验室超分子光化学研究中心和“理化青年论坛”暨中科院青促会理化所分会邀请，美国科学院院士、加州理工学院Gregory C. Fu教授于2017年10月20日来理化所交流访问。
Professor Fu-Kuo Chang,Department of Aeronautics and Astronautics,Stanford University（图）
Department of Aeronautics and Astronautics,Stanford University Professor multi-functional materials
2015/6/18
Professor Chang's primary research interest is in the areas of multi-functional materials and intelligent structures with particular emphases on structural health monitoring, intelligent self-sensing ...
Wavelet Transform Analysis of Electromyography Kung Fu Strikes Data
Martial arts combat sports Kung Fu EMG wavelet transform impact
2015/4/30
In martial arts and contact sports strikes are performed at near maximum speeds. For that reason, electromyography (EMG) analysis of such movements is non-trivial. This paper has three main goals: fir...
A randomised placebo-exercise controlled trial of Kung Fu training for improvements in body composition in overweight/obese adolescents: the “Martial Fitness” study
Adolescents Obesity Exercise Martial arts
2015/4/21
The purpose of the study was to investigate if Chinese martial arts (Kung Fu, KF) might be effective for improving body composition, as well as being an appealing form of physical activity for inexper...
The Artist as Creator: The Theory of Art in Du Fu's Poems about Paintings
Aesthetics Classical Chinese Poetry Painting
2014/10/27
Du Fu is one of China's most celebrated and influential poets. His poems about paintings are a highly innovative subset of poems rich with imagery and emotion. Received ideas about these poems fail to...
Professor Fu-Sheng Wu，Department of Languages and Literature at the University of Utah
Professor Fu-Sheng Wu Department of Languages and Literature at the University of Utah
2014/3/6
Professor Fu-Sheng Wu，Department of Languages and Literature at the University of Utah; “Farmstead and Pastoral Poetry, a Comparative Interpretation.” Nankai University, China, June 26, 2013. Invited...
5-Fu联合HER家族靶向药物对食管癌细胞增殖影响
Her家族 靶向治疗 食管鳞状细胞癌
2014/5/27
观察常规化疗药物联合表皮长因子受体（EGFR）靶向药物C225及人表皮生长因子受体-2（HER2）靶向药物trastuzumab对食管鳞状细胞癌细胞株HE-2增殖影响。方法 常规化疗药物5-Fu分别与C225及trastuzumab联合应用于食管鳞状细胞癌细胞株HE-2，采用噻唑蓝法以及流式细胞仪检测不同处理组的抗肿瘤效果。结果 5-Fu 联合C225作用24、48 h时，HE-2细胞增殖抑制率分...
研究减数分裂重组蛋白11(MRE11)基因沉默对5-氟尿嘧啶（5-FU）耐药的肝癌细胞株Bel7402/5-FU的化疗敏感性及耐药相关蛋白1(MRP1)表达的影响, 探讨MRE11与肝癌耐药性的关系。方法 采用阳离子脂质体法将shMRE11干扰质粒转染BEL7402/5-FU细胞, 实时定量PCR（qRT-PCR）及Western blot法检测沉默效率; MTT法检测转染后BEL7402/5-F...
对黄芩苷和5-FU在不同给药方案联合效应的依赖性进行研究。方法 通过体外人恶性肿瘤细胞系和正常细胞系的抗细胞增殖试验、细胞周期分布及凋亡试验，分别对应用黄芩苷和5-FU 3种联合方案(同时给药或序贯给药)进行效果评估。结果 等效线图解法和Chou-Talalay法的定性定量评估结果表明，相比同时给药方案，5-FU给药前给予适当剂量的黄芩苷不仅具有更显著的协同抗肿瘤活性，而且还可减小5-FU对正常细...