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A Penalized Multi-trait Mixed Model for Association Mapping in Pedigree-based GWAS
Multivariate linear mixed model Penalization approach Feature selection 1 arXiv:1305.4413v1 [stat.ME] 19 May 2013 GWAS
2013/6/14
In genome-wide association studies (GWAS), penalization is an important approach for identifying genetic markers associated with trait while mixed model is successful in accounting for a complicated d...
Efficient computation with a linear mixed model on large-scale data sets with applications to genetic studies
Efficient computation a linear mixed model on large-scale data sets applications genetic studies
2012/9/19
Motivated by genome-wide association studies we consider astan-dard linear model with one additional random effect in situations where many predictors have been collected on the same subjects and each...
A Poisson Mixed Model with Nonnormal Random Effect Distribution
Count data Generalized log-gamma distribution Multivariate negative binomial distribution Overdispersion Random-effect models
2011/6/17
We propose in this paper a random intercept Poisson model in which the random effect distribution
is assumed to follow a generalized log-gamma (GLG) distribution. We derive the first two moments
for...
A Note on an R^2 Measure for Fixed Effects in the Generalized Linear Mixed Model
Goodness-of-fit Correlated data Model selection Multiple correlation Maximum likelihood Nonnormal distribution
2010/11/8
Using the LRT statistic, a model V# is proposed for the generalized linear mixed model for
assessing the association between the correlated outcomes and fixed effects. The V# compares
the full model...
Analysis of 24-Hour Ambulatory Blood Pressure Monitoring Data using Orthonormal Polynomials in the Linear Mixed Model
Cubic Spline DASH Study Graphical Display
2010/10/19
The use of 24-hour ambulatory blood pressure monitoring (ABPM) in clinical practice and observational epidemiological studies has grown considerably in the past 25 years. ABPM is a very effective tech...
Generalised linear mixed model analysis via sequential Monte Carlo sampling
generalised additive models longitudinal data analysis nonparametric regression sequential Monte Carlo sampler
2009/9/16
We present a sequential Monte Carlo algorithm for the Bayesian analysis of generalised linear mixed models (GLMMs). These models support a variety of interesting regression-type analyses, but performi...
Fence methods for mixed model selection
Adaptive fence consistency F-B fence finite sample performance GLMM linear mixed model model selection
2010/4/30
Many model search strategies involve trading off model fit with
model complexity in a penalized goodness of fit measure. Asymptotic
properties for these types of procedures in settings like linear
...