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通过胶体金法和化学发光法检测血清中的新型冠状病毒（2019-nCoV）特异性总抗体，对两种方法的敏感度和特异度等进行初步的比较和评价。方法 本研究采用回顾性研究方法，收集2020 年2 月5 日~ 25 日在襄阳市第一人民医院就诊的门诊和住院患者病例119 例，根据《新型冠状病毒肺炎诊疗方案（试行第六版）》标准分为确诊病例组28 例，疑似病例组53 例，健康对照组38 例。采用胶体金试剂盒和全自动...
Inhibition of SARS-CoV-2 (Previously 2019-nCoV) Infection by a Highly Potent Pan-Coronavirus Fusion Inhibitor Targeting Its Spike Protein That Harbors a High Capacity to Mediate Membrane Fusion
Inhibition SARS-CoV-2 Pan-Coronavirus Fusion Inhibitor Targeting High Capacity Mediate Membrane Fusion
2020/6/12
The recent outbreak of coronavirus disease (COVID-19) caused by SARS-CoV-2 infection in Wuhan, China has posed a serious threat to global public health. To develop specific anti-coronavirus therapeuti...
Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes
2019-nCoV Wuhan pneumonia epidemiology swabs intestine
2020/6/12
In December 2019, a novel coronavirus (2019-nCoV) caused an outbreak in Wuhan, China, and soon spread to other parts of the world. It was believed that 2019-nCoV was transmitted through respiratory tr...
Fusion mechanism of 2019-nCoV and fusion inhibitors targeting HR1 domain in spike protein
Fusion mechanism 2019-nCoV inhibitors targeting HR1 domain spike protein
2020/6/12
Very recently, a novel coronavirus, 2019-nCoV, emerged in Wuhan, China and then quickly spread worldwide, resulting in >17,388 confirmed cases and 361 deaths as of 3 February 2020, thus calling for th...
Clinical Features and Treatment of 2019-nCov Pneumonia Patients in Wuhan: Report of A Couple Cases
Clinical Features Treatment 2019-nCov Pneumonia Patients Wuhan
2020/6/12
Till January 20, 2020, the 2019-new coronavirus (2019-nCoV) has caused more than one hundred cases in Wuhan (WMHC 2020). During a retrospective study of recent pneumonia patients in our department, we...
Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro
Remdesivir chloroquine effectively inhibit novel coronavirus (2019-nCoV) vitro
2020/6/12
In December 2019, a novel pneumonia caused by a previously unknown pathogen emerged in Wuhan, a city of 11 million people in central China. The initial cases were linked to exposures in a seafood mark...