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Multiple myeloma is an incurable bone marrow cancer that kills over 100,000 people every year. Known for its quick and deadly spread, this disease is one of the most challenging to address. As these c...
Over the past decade, the approval of immune checkpoint inhibitors has revolutionized treatment for patients with advanced lung cancer, helping many live longer lives and improving overall survival fo...
In the five years since the FDA’s initial approval of chimeric antigen receptor (CAR) T cell therapy, Penn Medicine has gleaned 20 additional approvals related to drugs and techniques to treat or dete...
A novel cancer therapeutic, combining antibody fragments with molecularly engineered nanoparticles, permanently eradicated gastric cancer in treated mice, a multi-institutional team of researchers fou...
Treating cancer with combinations of drugs can be more effective than using a single drug. However, figuring out the optimal combination of drugs, and making sure that all of the drugs reach the right...
“JUPITER-06研究聚焦中国高发的食管鳞癌人群,并且应用了国产原研的免疫治疗制剂,有利于解决我国患者的治疗需求缺口,符合国家重大战略需求。”中山大学肿瘤防治中心主任徐瑞华教授在3月5日广州举行的“中山大学肿瘤防治中心食管癌免疫治疗领域重大研究成果新闻发布会”上表示。
带有开放阅读框(ORFs)的RNA只占基因组总RNAs的不到2%,其余98%的RNAs均为非编码RNA(ncRNAs),环状RNA(circRNA)即是其中一类。大量证据表明ncRNAs不仅参与细胞应答和细胞命运决定的调控,也在肿瘤发生和进展中发挥重要作用。因此,识别肿瘤中异常表达的ncRNAs,对于进一步理解肿瘤发生及进展的机制具有极其重要的作用,也是肿瘤诊断和靶向特定分子进行精准治疗的必要途径...
2022年1月6日,湘雅肿瘤医学中心、分子放射肿瘤学湖南省重点实验室孙仑泉教授、邓跃臻教授团队在国际知名学术期刊《Cancer Research》 (Q1, 影响因子12.7,自然指数期刊)、《Int J of Biol Sci》(Q1, 即时影响因子8.7)同时发表2篇研究论文,揭示非小细胞肺癌发生和治疗抵抗新机制。
Over the past few decades, scientists have made great strides in understanding the genetic mutations that can drive cancer. For some types of cancer, these discoveries have led to the development of d...
Non-small cell lung cancer (NSCLC) is the most common type of lung cancer in humans. Some patients with NSCLC receive a therapy called immune checkpoint blockade (ICB) that helps kill cancer cells by ...
近日,重庆医科大学基础医学院陈俊霞教授团队在国际著名肿瘤学期刊《Molecular Cancer》上在线发表了题为“The circACTN4 interacts with FUBP1 topromote tumorigenesis and progression ofbreast cancer by regulating the expressionof proto-oncogene MYC”的...
2021年5月18日,山东大学齐鲁医院史本康教授和山东大学基础医学院龚瑶琴团队的邹永新副教授联合在Molecular Cancer杂志(中科院1区, IF=15.302)发表题为“KDM6A-ARHGDIB axis blocks metastasis of bladder cancer by inhibiting Rac1”的研究论文。山东大学齐鲁医院医师刘磊和山东大学临床医学院博士研究生崔剑锋...
2021年5月11日,浙江大学医学院那仁满都拉教授团队和许志宏研究员团队在美国癌症协会(AACR)重磅打造的新期刊Blood Cancer Discovery上在线发表了研究论文Hyperthermia Selectively Destabilizes Fusion Oncoproteins (https://bloodcancerdiscov.aacrjournals.org/content/e...
近日,上海市肿瘤研究所田华研究团队在国际著名肿瘤学期刊CancerResearch杂志在线发表了题为“ApositivefeedbackloopofAKR1C3-mediatedactivationofNF-κBandSTAT3facilitatesproliferationandmetastasisinhepatocellularcarcinoma”的研究论文。该研究揭示了AKR1C3在肝细胞癌...
2020年3月16日,中南大学湘雅医院皮肤科、中南大学湘雅个体化肿瘤免疫治疗临床研究中心黑素瘤研究团队在国际顶尖刊物Cancer Cell上发表题为“ADORA1 inhibition promotes tumor immune evasion by regulating the ATF3-PD-L1 axis”的研究论文。这项研究的第一作者和通讯作者单位均为中南大学湘雅医院皮肤科。刘洪教授和匡欣...

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