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Reversal of testicular function after prolonged suppression with an LHRH agonist in rhesus monkeys
testicular function prolonged suppression LHRH agonist rhesus monkeys
2009/2/23
Using subcutaneously implanted osmotic pumps, four male rhesus monkeys were continuously infused for 18 months with 100 micrograms/day of [(imBzl)-D-His6-Pro9-NEt]-LHRH (LHRH-A), a potent agonist of...
Lack of correlation between fertility and sperm numbers in male rats treated with histrelin, a potent LHRH agonist
correlation fertility sperm numbers male rats histrelin potent LHRH agonist
2009/2/23
Adult male rats were treated daily for up to 8 weeks with histrelin, [(ImBzl)-D-His6, Pro9-NEt]LHRH, to study the antifertility effects of this LHRH agonist. Although serum testosterone concentratio...
Dose-response studies on male reproductive parameters in dogs with nafarelin acetate, a potent LHRH agonist
LHRH agonist nafarelin acetate EDNal(2)6JLHRH spermatogenesis prostate male dogs
2009/2/20
Adult male beagle dogs were administered daily subcutaneous injections of either 0.5 or 2.0 micrograms/kg of a potent LHRH agonist, nafarelin acetate, for 44 days. Although there was a rise in the c...
Recovery of gonadal functions in the adult male rat following cessation of five-month daily treatment with an LHRH agonist
LHRH agonist testicular steroidogenesis ventral prostate seminal vesicles spermatogenesis
2009/2/20
This study describes the recovery of various parameters of the pituitary-gonadal axis following five months of daily treatment of adult male rats with a potent LHRH (luteinizing hormone-releasing ...
Effects of an LHRH agonist analog upon sexual function in male dogs. Suppression, reversibility, and effect of testosterone replacement
LHRH agonists D-Na!(2)6-LHRH spermatogenesis
2009/2/20
Male beagle dogs were injected once daily with 10 micrograms/kg of [6-D-(2-naphthyl)alanine]-LHRH (D-Nal(2)6-LHRH), a potent LHRH agonist, for periods up to 42 days, with recovery periods up to 172 ...
Combined treatment with an LHRH agonist and testosterone in man. Reversible oligozoospermia without impotence
LHRH (GnRH) testosterone spermatogenesis
2009/2/19
We have previously shown that LHRH agonist [D-Trp6,Pro9-NEt]LHRH (LHRHA) results in reversible oligozoospermia when given to normal subjects for up to ten weeks. A fall in plasma testosterone was ac...
In Vivo and In Vitro Investigation of the Extrapituitary Antireproductive Effects of a Potent LHRH Agonist in Immature and Adult Male Rats
LHRH agonist extrapituitary reproductive effects age-dependency hypophysectomy
2009/2/19
Co-incubation with a potent LHRH agonist, D-Ala6-Des-Gly10-Pro9-NHEt-LHRH (Wy-18,481), did not affect testosterone or progesterone production by adult intact rat testes in vitro. Prior administrat...
Effects of Chronic, High-dose LHRH-Agonist Treatment on Pituitary and Testicular Functions in Rhesus Monkeys
Chronic High-dose LHRH-Agonist Treatment Pituitary Testicular Functions Rhesus Monkeys
2009/2/18
The effects of chronic, high-dose treatment with an LHRH-agonist (D-Ser-(TBu)6-LHRH-ethylamide) on pituitary and testicular functions were investigated in four adult rhesus monkeys in-season. Doses ...