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血清总IgE(total IgE, tIgE)抗体和过敏原特异性IgE(specific IgE,sIgE)抗体是过敏性疾病的重要检测项目,其结果有赖于与临床表现结合进行分析判断,检验医师和临床医师须具备对检验结果的解读能力。该文综述血清IgE检测结果与临床表现的相关性,包括:血清tIgE和过敏原sIgE浓度与过敏症状的关系、检测结果与症状不相符的情况、tIgE的临界值等,为检验医师和临床医师正确...
探讨IgE介导的哮喘患儿呼出气一氧化氮(FeNO)与气道可逆性的相关性。方法 选取2016年9月至2018年8月初诊为哮喘急性发作的6~14岁患儿86例为研究对象,根据血清特异性IgE结果分为IgE介导组(n=61)及非IgE介导组(n=25),根据过敏原检测结果将IgE介导组进一步分为1、2、3种和4种及以上过敏原阳性组。检测FeNO水平及支气管舒张试验前后常规通气肺功能指标,采用Pearson...
慢性阻塞性肺疾病患者血清IgE水平及其临床意义
血清IgE 变应原 肺疾病,慢性,阻塞性 表型
2020/6/28
探讨慢性阻塞性肺疾病 ( COPD)患者总I gE( t I gE)及特异性I gE ( s I gE)水平与COPD表型、急性加重、肺功能的关系。方法 采用过敏反应体外试剂盒测定 294例已确诊的COPD患者血清t I gE及s I gE水平。同时收集病史、评估患者临床症状、肺功 能、外周血嗜酸粒细胞计数、急性加重住院次数等资料。
探讨非急性发作期支气管哮喘患者呼出气一氧化氮(FeNO)浓度与肺功能及血清白细胞介素-17(IL-17),免疫球蛋白E(IgE)水平的相关性。方法:拾取125例非急性发作期支气管哮喘患者,根据急性控制测试(ACT)评分进行分组:控制组(40例),部分控制组(45例),未控制组(40例)。另选40例体检对几组研究对象进行FeNO,肺功能指标及血清IL-17,IgE检测。对比几组的检测结果,并分析AC...
分析小儿支气管哮喘患者治疗前、后血清基质金属蛋白酶-9(MMP-9)、基质金属蛋白酶组织抑制剂-1(TIMP-1)、白细胞介素-18(IL-18)及免疫球蛋白E(IgE)水平变化,并探讨联合检测各项指标对疾病预判及疗效观察的临床应用价值。方法 选取92例小儿支气管哮喘患者(观察组)及30例小儿健康体检者(对照组)为研究对象,采用酶联免疫法(ELISA)检测对照组及观察组治疗前后血清MMP-9、TI...
目的 观察卡介菌多糖核酸(BCG-PSN)联合特异性脱敏治疗(SIT)对支气管哮喘缓解期患者气道反应性的影响。 方法 选择支气管哮喘缓解期患者70例,随机分为3组,分别给予BCG-PSN、SIT及BCG-PSN+SIT(联合治疗组)治疗,并比较3组治疗后气道反应性、血清IgE及白细胞介素-4(IL-4)水平的变化。 结果 联合治疗组治疗2月后气道反应性改善值第1秒用力呼气量%改善值(△FEV1%)...
The Effect of Exam Stress on Serum IL-6,Cortisol,CRP and IgE Levels
Stress Immune system IL-6 IgE CRP Cortisol
2015/9/21
Background: Stress has determining effects on the immune response. This study was undertaken to determine the effect of exam stress on serum IL-6, cortisol, CRP and IgE levels of medical students.
Clinical Evaluation of Total IgE in Tears of Patients with Allergic Conjunctivitis Disease Using a Novel Application of the Immunochromatography Method
allergic conjunctivitis disease immunochromatography immunoglobulin E
2010/11/16
The positive ratio obtained by this novel application of the immunochromatography assay was 38 of the 41 in the patients with ACD and none in the 7 controls. IgE indices for the VKC group, AKC group a...
Enzyme-Linked Immunosorbent Assays with High Sensitivity for Antigen-Specific and Total Murine IgE: A Useful Tool for the Study of Allergies in Mouse Models
allergen-specific IgE blocking reagent enzyme-linked immunosorbent assay
2010/11/16
Enhancer solutions are effective in improving ELISAs for total and antigen-specific murine IgE. Selection of blocking reagents was important to decrease unwanted enhancement of background signals and ...
Antigen-Induced Expression of CD203c on Basophils Predicts IgE-mediated Wheat Allergy
basophil activation test CD203c omega-5 gliadin wheat allergy
2010/11/16
All wheat proteins induced concentration-dependent enhancement of CD203c expression in WA, but did not in TW. The analysis of receiver operating characteristics (ROC) showed that nOG5-induced CD203chi...
IgE Profiles of Bermuda Grass Pollen Sensitised Patients Evaluated by Phleum Pratense Allergens Phl P 1, 2, 4, 5, 6 , 7, 11, 12
Bermuda grass recombinant allergens timothy grass
2010/11/17
Our data show that all BGP-allergic patients simultaneously exhibit higher IgE antibody levels to recombinant and natural P. pratense allergens as well as to crude TGP extract. This suggests that when...
Detection of Specific IgE Antibodies in Sera of Japanese Birch-Allergic Patients Using Recombinant Allergens Bet v 1, Bet v 2 and Bet v 4
Bet v 1 Bet v 2 birch pollinosis RAST
2010/11/17
Background: Birch pollen is the major allergen in pollinosis in northern Japan. IgE reactivity to individual birch pollen allergens has been shown to differ between populations of birch pollen-allergi...
Three Cases of Ortho-phthalaldehyde-induced Anaphylaxis after Laryngoscopy: Detection of Specific IgE in Serum
basophils ELISA histamine release IgE-mediated anaphylaxis skin test
2010/11/18
Background: Ortho-phthalaldehyde (OPA) has recently been used as a disinfectant for various medical apparatuses. OPA is not generally recognized as a potential allergen.
Case Summary: Subsequent to o...
Detection of serum IgE antibody directed to aminothiazole using immobilized cephalosporins without protein conjugation
antibiotics contact dermatitis contact urticaria drug allergy enzyme-linked immunosorbent assay immunoglobulin E
2010/11/29
It is well known that allergic reactions may sometimes occur in patients under treatment with β-lactam antibiotics. For the detection of antidrug antibodies in vitro, conjugation with human serum albu...
Distribution of specific serum IgE to recombinant pollen allergens (rPhlp1, rPhlp2, rPhlp5, and rBetv2) and their relationship to each other and to their natural counterparts in patients allergic to grass pollen
rBetv2 recombinant allergens rPhlp1 rPhlp2 rPhlp5 timothy grass
2010/11/25
Recombinant pollen allergens rPhlp1, rPhlp2, rPhlp5, and rBetv2 may function as effective markers of atopy and account for a substantial proportion of grass pollen-specific IgE. The purpose of the pre...