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The hypothalamic-pituitary-adrenal axis (HPA) is a complex system regulated by multiple factors. Sexual dimorphism of this axis has been described in different species under physiological conditions...
中科院上海药物研究所杨春皓研究组在进行新型抗肿瘤药物研发的同时,还积极致力于以生物活性为导向的杂环合成方法学研究,为研究组的新药发现奠定化学基础。研究组利用一些人们熟知的、简单易得的有机小分子(如苯乙腈类,邻羟基苯乙酮类——an old dog)为起始原料,发展新的方法(New tricks)用以快速构建结构多样的具有类药性的杂环化合物。
苯乙腈类化合物是一类人们熟知的重要有机化学及药物化学中间体(an old dog),如何利用这样简单的分子合成一些药物化学的优势结构或活性分子不但充满了吸引力,而且具有一定的挑战性。
Extruded dry dog food products claimed to have a probiotic ingredient of Enterococcus faecium (NCIMB10415) in the commercial available formulations under the brand name of ProBiotic LIVE (Bacterfield ...
The University of Queensland (UQ) veterinarians are urging dog owners to vaccinate their pets against the deadly canine parvovirus.
Background: In patients with ulcerative colitis (UC), the repeated cycle of injury and repair of intestinal mucosa has been reported to increase the risk of colon cancer. So, a safe and efficient ther...
The effects of prolonged administration of methylthiouracil were studied on several physiological parameters pertinent to the thyroid function in dog. Though the individual variations of the measured...
The study on the serum protein electrophoresis following thyroidectomy in A puppies showed a significant decrease in the albumin and -a-ratio associated with a relative increase in gamma and total glo...
Background: To investigate the healing effects of vitreous body in repair of cartilage defects of the knee joint in dog as an animal model.
Experiments were performed to determine the influence of varying inspired oxygen tension on renal prostaglandin E2 (PGE2) excretion, renal hemodynamics, and water and electrolyte excretion in the cons...
Recent studies have documented a marked inhibition of renal prostaglandin E2 excretion during hyperbaric oxygenation (HBO) in the conscious dog. Numerous other studies have shown that pharmacological ...
Unsuccessful cadaveric kidney transplantation still remains as an important problem in organ transplantation. Cold storage solutions are not very efficient for kidney preservation. Vitamin E is an imp...
It is known that hyperbaric oxygenation (HBO) decreases total coronary blood flow (TCBF) and cardiac output (CO). To determine whether this is related to an alteration in myocardial contractility, 10 ...
Introduction: This study was carried out in order to compare mineral trioxide aggregate (MTA) and dycal in dog’s teeth as pulp capping agents.Methods: After general and local anesthesia forty-two te...
Introduction: The materials used in sealing furcating perforation can have considerable effects on controlling the ensuing inflammation and periodontal repair. The objective of the present study was...

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