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Huge libraries of drug compounds may hold potential treatments for a variety of diseases, such as cancer or heart disease. Ideally, scientists would like to experimentally test each of these compounds...
With the release of platforms like DALL-E 2 and Midjourney, diffusion generative models have achieved mainstream popularity, owing to their ability to generate a series of absurd, breathtaking, and of...
《The overview of studies on huperzine A: a natural drug for the treatment of Alzheimer's disease》
中国科学院 上海药物研究所 阿尔茨海默病
2023/2/22
《The overview of studies on huperzine A: a natural drug for the treatment of Alzheimer's disease》
《个性化药物： 新药研发的未来Personalized medicines, the future of drug discovery》
个性化药物 上海科学技术文献出版 上海药物研究所
2023/2/21
个性化药物： 新药研发的未来Personalized medicines, the future of drug discovery
Brown researchers develop new, automated, powerful diagnostic tool for drug detection（图）
药物检测 诊断工具 生物医学 抗抑郁药
2023/6/26
The work by a research team made up largely of Brown graduate and undergraduate students addresses a critical biomedical need and has the potential to be widely adapted by clinicians to monitor antide...
上海市肿瘤研究所金浩杰研究员和Rene Bernards院士合作在Nature Reviews Drug Discovery杂志发表长篇综述文章：癌症联合靶向治疗的背景、优势与挑战（图）
金浩杰研究员 癌症 肿瘤药物 肿瘤细胞
2023/1/13
近日，上海市肿瘤研究所金浩杰研究员与René Bernards院士作为共同通讯作者在Nature Reviews Drug Discovery期刊上发表了长篇综述文章“Rational combinations of targeted cancer therapies: background, advances and challenges”，对癌症联合靶向治疗策略的背景、优势及面临的挑战进行全面...
Over the past few decades, very few new antibiotics have been developed, largely because current methods for screening potential drugs are prohibitively expensive and time-consuming. One promising new...
Over the past few decades, scientists have made great strides in understanding the genetic mutations that can drive cancer. For some types of cancer, these discoveries have led to the development of d...
Researchers at MIT and Dana-Farber Cancer Institute have developed a new way to determine whether individual patients will respond to a specific cancer drug or not. This kind of test could help doctor...
真菌性角膜炎是一种由致病真菌引起的致盲率极高的眼部感染性疾病。若感染早期未及时诊断和治疗，炎症则会迅速进展，引起角膜混浊、溃疡、穿孔，不仅会导致严重的眼内炎，还会导致颅内感染扩散。那他霉素是唯一一个被美国食品药品监督管理局批准用于控制真菌性角膜炎的滴眼液，具有抗菌谱广、抗菌能力强、不良反应少等优点。但是那他霉素难溶于水，目前市面上只有5%的那他霉素悬浊液（那特真）存在。那特真价格昂贵，除此之外，由...
Pancreatic cancer, which affects about 60,000 Americans every year, is one of the deadliest forms of cancer. After diagnosis, fewer than 10 percent of patients survive for five years.
Structural Basis for the Inhibition of SARS-CoV-2 Main Protease by Antineoplastic Drug Carmofur
SARS-CoV-2 cross-neutralizing antibody receptor binding motif spike protein substitution mutation
2020/6/11
The antineoplastic drug carmofur is shown to inhibit the SARS-CoV-2 main protease (Mpro). Here, the X-ray crystal structure of Mpro in complex with carmofur reveals that the carbonyl reactive group of...
NSF provides support for drug discovery platform for hard-to-treat cancers（图）
NSF provides support drug discovery platform hard-to-treat cancers
2020/5/9
A new round of support will help a Purdue University-affiliated startup further develop a platform designed to create drugs for people with hard-to-treat cancers.Akanocure Pharmaceuticals, Inc., ...
The anti-influenza virus drug, arbidol is an efficient inhibitor of SARS-CoV-2 in vitro
The anti-influenza virus drug arbidol efficient inhibitor SARS-CoV-2 in vitro
2020/6/11
Since December 2019, a novel disease COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rapidly spread to over 200 countries and infected over 1.50 million people includin...
AI accelerating drug discovery to fight COVID-19（图）
AI accelerating drug discovery fight COVID-19
2020/5/9
Researchers are running a global race to discover a vaccine, drug or combination of treatments that can disrupt the SARS-CoV-2 virus, which causes the COVID-19 disease, and prevent widespread deaths.M...