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Much of the human genome is made of regulatory regions that control which genes are expressed at a given time within a cell. Those regulatory elements can be located near a target gene or up to 2 mill...
南京农业大学农学院《Plant Biotechnology Journal》发表国家大豆改良中心杨守萍教授团队“The miR156b-GmSPL2b module mediates male fertility regulation of cytoplasmic male sterility-based restorer line under high-temperature stress in soybean”（图）
大豆改良 杨守萍 基因资源
2023/10/28
2023年4月18日，南京农业大学杨守萍教授团队在《Plant Biotechnology Journal》上在线发表了题为“The miR156b-GmSPL2b module mediates male fertility regulation of cytoplasmic male sterility-based restorer line under high-temperature st...
Despite the sheer number of genes that each human cell contains, these so-called “coding” DNA sequences comprise just 1 percent of our entire genome. The remaining 99 percent is made up of “non-coding...
2018年冷泉港亚洲会议：Systems Biology of Gene Regulation&Genome Editing（Cold Spring Harbor Asia conference on Systems Biology of Gene Regulation & Genome Editing）
2018年 冷泉港亚洲会议 Systems Biology of Gene Regulation&Genome Editing
2018/1/12
We are pleased to announce the Cold Spring Harbor Asia conference on Systems Biology of Gene Regulation & Genome Editing which will be held in Suzhou, China, located approximately 60 miles west of Sha...
Regulation of mTORC1 by growth factors,energy status,amino acids and mechanical stimuli at a g lance
mTORC1 Akt Myostatin Muscle protein synthesis
2016/5/16
The mechanistic/mammalian target of rapamycin c omplex 1 (mTORC1) plays a pivotal r ole in the regulation of skeletal muscle protein synthesis. A ctivation of the c omplex leads to phosphorylation of ...
Researchers shed new light on regulation of repetitive DNA sequences
Researchers repetitive DNA sequences
2016/2/22
A pair of studies by a team of scientists has shed new light on the nature of a particular type of DNA sequences—tandem DNA repeat arrays—that play important roles in transcription control, genome org...
RNA, once thought to be a mere middleman between DNA and protein, is now recognized as the stage at which a host of regulatory processes can act to allow for flexibility in gene expression and thus th...
Many Experiments for the Price of One:A Breakthrough in the Study of Gene Regulation
Price of One Gene Regulation
2015/6/18
Inside every cell that makes up a diminutive fruit fly is a vast, dynamic network of information—the genome whose ~15,000 genes allow that cell to function. In a study recently published as a Br...
Identification of a Minimal Cis-element and Cognate Trans-factors Required for the Regulation of Rac2 Gene Expression during K562 Cell Differentiation
Rac2 Gene Expression
2015/5/25
This dissertation examines the molecular mechanisms regulating Rac2 gene expression during cell differentiation and identification of a minimal cis-element required for the induction of Rac2 gene expr...
Regulation of Exocytosis by Syntaxin 4-Munc18c Complexes
Munc18c Syntaxin 4 SNARE diabetes
2015/5/25
Type 2 diabetes involves defects in glucose-stimulated insulin secretion (GSIS) from the pancreatic beta cells in combination with defects in peripheral (muscle and adipose) tissue glucose uptake. Bot...
ELUCIDATING THE ROLE OF REDOX EFFECTS AND THE KU80 C-TERMINAL REGION IN THE REGULATION OF THE HUMAN DNA REPAIR PROTEIN KU
DNA-PKcs regulation Ku NHEJ
2015/5/25
DNA double strand breaks (DSB) are among the most lethal forms of DNA damage and can occur as a result of ionizing radiation (IR), radiomimetic agents, endogenous DNA-damaging agents, etc. If left unr...
TRANSCRIPTIONAL REGULATION OF THE HUMAN ALCOHOL DEHYDROGENASES AND ALCOHOLISM
exon arrays differential gene expression alternative splicing
2015/5/25
Alcohol dehydrogenase (ADH) genes encode proteins that metabolize ethanol to acetaldehyde. Humans have seven ADH genes in a cluster. The hypothesis of this study was that by controlling the levels of ...
In Vivo Analysis of Human LHX3 Gene Regulation
Gene Regulation Pituitary Combined Pituitary Hormone Deficiency LHX3
2015/5/25
LHX3 is a transcription factor important in pituitary and nervous system development. Patients with mutations in coding regions of the gene have combined pituitary hormone deficiency (CPHD) that cause...
SETD1 HISTONE 3 LYSINE 4 METHYLTRANSFERASE COMPLEX COMPONENTS IN EPIGENETIC REGULATION
EPIGENETICS H3K4 METHYLTRANSFERASE
2015/5/25
Setd1 histone 3 lysine 4 methyltransferases are critical for epigenetic regulation and gene expression. Setd1a is multiprotein complex comprised of several critical subunits including wdr82, which is ...
Phospho-regulation and metastatic potential of Murine Double Minute 2
Metastasis Phosphorylation c-Src
2015/5/25
Murine double minute (Mdm2) is a highly modified and multi-faceted protein that is overexpressed in numerous human malignancies. It engages in many cellular activities and is essential for development...