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Transcriptional regulation of ATF4 is critical for controlling the Integrated Stress Response during eIF2 phosphorylation
Transcriptional regulation ATF4
2015/5/25
In response to different environmental stresses, phosphorylation of eIF2 (eIF2P) represses global translation coincident with preferential translation of ATF4. ATF4 is a transcriptional activa...
REGULATION OF CHOP TRANSLATION IN RESPONSE TO eIF2 PHOSPHORYLATION AND ITS ROLE IN CELL FATE
Stress (Physiology) Messenger RNA Apoptosis
2015/5/25
In response to different environmental stresses, phosphorylation of eukaryotic initiation factor-2 (eIF2) rapidly reduces protein synthesis, which lowers energy expenditure and facilitates reprogrammi...