搜索结果: 1-15 共查到“生物学 Mutations”相关记录16条 . 查询时间(0.078 秒)
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Portland State research shows some viruses can infect even after major mutations
Portland State research some viruses infect
2017/3/30
Portland State University researchers have found that only about half the genes in a specific virus affecting single cell organisms is needed to infect a host. This means the virus can undergo major m...
Model expands landscape for signaling protein mutations
Model expands landscape signaling protein
2016/11/4
Protein pairs that control stimulus response in bacteria maintain a sensitive balance between interaction specificity and promiscuity, according to Rice University scientists.A computational model dev...
Missense mutations in exon 2 of the porcine leptin receptor gene and their associations with litter size and body weight
LEPR SNPs pigs
2015/6/8
Leptin receptor (LEPR) gene is regarded as a “candidate-gene” of production traits. The aims of this study were to detect polymorphisms of exon 2 within LEPR gene and to investigate their associations...
Modulation of epidermal growth factor receptor function by mutations within the actin -binding domain
Genes actin internalization growth factors tyrosine phenylalanine glutamic acid phenylalanine residues
2014/12/11
The generation of site-directed mutants within the actin binding domain of the EGF receptor modulates receptor function in internalization and ligand binding. In addition, truncation of the EGFr at re...
Molecular and functional analysis of mutations that result in insecticide resistance in Colorado potato beetle
Gene mutations pain and the potato beetle biological molecules the rate constant
2014/12/11
The functional aspects of specific mutations, R30K, S291G, and I392T, found associated with AChE gene of OP- and carbamate-resistant Colorado potato beetle (CPB) were determined using recombinant AChE...
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Classification of gene mutations in a children's cancer may point to improved treatments(图)
gene cancer
2014/12/1
Oncology researchers studying gene mutations in the childhood cancer neuroblastoma are refining their diagnostic tools to predict which patients are more likely to respond to drugs called ALK inhibito...
Fifteen years ago, MIT professor John Essigmann and colleagues from the University of Washington had a novel idea for an HIV drug. They thought if they could induce the virus to mutate uncontrollably,...
Mutations of TYR and MITF Genes are Associated with Plumage Colour Phenotypes in Geese
Goose TYR and MITF Gene SNP Plumage Colour
2016/5/16
The polymorphism of microphthalmia-associated transcription factor (MITF) and tyrosinase (TYR) genes have been proposed to play a vital role in coat colour genesis in mammals, but their role remains a...
Soluble oligomerization provides a beneficial fitness effect on destabilizing mutations
Soluble oligomerization beneficial fitness effect destabilizing mutations Biomolecules
2012/4/28
Mutations create the genetic diversity on which selective pressures can act, yet also create structural instability in proteins. How, then, is it possible for organisms to ameliorate mutation-induced ...
北京师范大学分子生物学课件CHAPTER 6 Mutations, Mutagenesis and DNA Repair
北京师范大学 分子生物学 课件 Mutations Mutagenesis DNA Repair
2009/11/14
北京师范大学分子生物学课件CHAPTER 6 Mutations, Mutagenesis and DNA Repair。
缺血性脑卒中患者同型半胱氨酸代谢相关酶基因突变的研究 Genetic Mutations of Homocysteine Metabolism Related Enzymes in Patients with Ischemic Stroke
缺血性脑卒中 胱硫醚—β—合成酶 亚甲基四氢叶酸还原酶 基因突变 基因频率
2008/1/8
摘要
为研究同型半胱氨酸代谢相关酶亚甲基四氢叶酸还原酶(MTHFR)基因C677T和胱硫醚-β-合成酶(CBS)基因T833C位碱基突变与缺血性脑卒中的关系,对74例缺血性脑卒中患者和83例健康对照者, 采用聚合酶链反应—限制性片段长度多态性(PCR-RFLP)技术检测MTHFR基因 C677T基因型, 用扩增阻滞突变体系法(ARMS)检测CBS基因T833C突变。实验检出患者组MTHFR基因T...
胞质异质性——人类肿瘤组织线粒体基因突变的普遍现象Heteroplasmy: A Common Phenomenon of Mitochondrial Genome Mutations in Human Tumor Tissues
线粒体基因 突变 异质性 同质性 肿瘤
2008/1/6
为了探讨不同肿瘤组织中线粒体基因体细胞性突变的胞质异质性和同质性状态,利用32对重叠引物对149例肿瘤组织和匹配的正常组织的全线粒体基因进行PCR扩增,并同时进行时相温度梯度凝胶电泳扫描突变筛选,基因测序确定突变类型与异质状况。结果表明,不同肿瘤组织中线粒体基因体细胞性突变的异质率不同,口腔癌(65%)和食道癌(64%)具有较高的异质率,其次为乳腺癌(45.9%)。4种转换形式的发生频率Hm→Hm...
肝癌组织中线粒体DNA D-Loop区碱基变异与ROS水平Mutations in the D-Loop Region of Mitochondrial DNA and the ROS Level in the Tissue of Hepatocellular Carcinoma
线粒体DNA D-Loop 原发性肝癌 突变 活性氧类物质
2008/1/6
摘要
为了探讨ROS水平与突变的关系,对原发性肝癌线粒体DNA区的突变情况进行研究,同时对原发性肝癌患者组织细胞内ROS进行测定。选择20例原发性肝癌组织及其邻近的癌旁组织,用PCR方法将线粒体DNA D-Loop扩增后测序。组织内ROS的水平采用流式细胞技术测定。结果表明在20对原发性肝癌组织中存在8对mtDNA突变,突变率为40%,共发现突变位点53个,包括2个插入,11个缺失...