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An Efficient Synthesis of (1 S , 2 R )-1-Amino-2-Indanol, A Key Intermediate of HIV Protease Inhibitor, Indinavir
Manganese(III) oxidation imine reduction enantioselective hydrolysis 1-amino-2-indanol
2010/6/28
(1S,2R)-1-amino-2-indanol, a key component of an HIV protease inhibitor is synthesized in four steps starting from indanone. The Mn(OAC)3 mediated acetoxylation of indanone followed by fungus catalyze...